Results 61 to 70 of about 4,745 (262)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Performing Critique: Queer Video Games as Critical Method
On_Culture, 2019 Against the backdrop of a growing concern for the fate of critique in the current era, queer video games such as tranxiety, Dream Daddy and Gone Home have begun to engage players in the process of critically examining their own assumptions and immersing ...
Joshua W. Rivers
doaj
The DykeGlobally, the surge of new media technologies, through social networking sites and mobile instant messaging platforms, have largely transformed the behavioural patterns of individuals and communities.
Langtone Maunganidze, Tadios Chisango
doaj +1 more source
Theory and migration. Towards a framework of migration and human actions
Cybergeo, 2004 The following article discusses the role of the human agency in migration theory. In connection to that special interest is focused on the structuration-theory where the human agent plays an important role.
Olof Stjernström
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
CLASSIFICATION OF THE MACHINE TECHNOLOGICAL SYSTEMS IN PLANT INDUSTRY
Сельскохозяйственные машины и технологии, 2015 The need of expansion of works on normalization and development of machine technologies system for transition to technologisation of agro-industrial production was defined.
V. M. Beylis
doaj