Results 151 to 160 of about 10,109,694 (374)

Entity-Relationship Search over the Web [PDF]

open access: yesarXiv, 2018
Entity-Relationship (E-R) Search is a complex case of Entity Search where the goal is to search for multiple unknown entities and relationships connecting them. We assume that a E-R query can be decomposed as a sequence of sub-queries each containing keywords related to a specific entity or relationship.
arxiv  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

First Total Syntheses and Antimicrobial Evaluation of Penicimonoterpene, a Marine-Derived Monoterpenoid, and Its Various Derivatives

open access: yesMarine Drugs, 2014
The first total synthesis of marine-derived penicimonoterpene (±)-1 has been achieved in four steps from 6-methylhept-5-en-2-one using a Reformatsky reaction as the key step to construct the basic carbon skeleton.
Jian-Chun Zhao   +3 more
doaj   +1 more source

Structure activity relationship (SAR) studies of neurotoxin quinoline-derivatives [PDF]

open access: yes, 2020
Structure activity relationship (SAR) studies are performed in order to identify the core structure that is responsible for the biological activity of an organic molecule.
Smeyne, Dylan
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Quantitative Structure Activity Relationship Models for the Antioxidant Activity of Polysaccharides

open access: yesPLoS ONE, 2016
In this study, quantitative structure activity relationship (QSAR) models for the antioxidant activity of polysaccharides were developed with 50% effective concentration (EC50) as the dependent variable.
Zhiming Li   +3 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Comprehensive review in moisture retention mechanism of polysaccharides from algae, plants, bacteria and fungus

open access: yesArabian Journal of Chemistry, 2022
Polysaccharides have attracted much attention due to their significant bio-activities. This review aims to summarize the main polysaccharides sources of related polysaccharides from algae, plants, fungus, and bacteria, and give insights into the ...
Tong Zhang, Qiwei Guo, Yu Xin, Yang Liu
doaj  

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