Results 141 to 150 of about 5,517,395 (407)
Synthesis and activity of novel indole derivatives as inhibitors of CD38
Acta Pharmaceutica Sinica B, 2013 CD38 is a multifunctional enzyme/receptor expressed in a variety of mammalian tissues, regulating a wide range of physiological functions. Beginning with the previously reported compound 1, an inhibitor of human CD38 NADase, we synthesized a series of ...
Dongying Wu +7 more
doaj +1 more source
Mining Essential Relationships under Multiplex Networks [PDF]
arXiv, 2015 In big data times, massive datasets often carry different relationships among the same group of nodes, analyzing on these heterogeneous relationships may give us a window to peek the essential relationships among nodes. In this paper, first of all we propose a new metric "similarity rate" in order to capture the changing rate of similarities between ...
arxiv
Structure-activity relationships of saframycins.
The Journal of Antibiotics, 1984 In vitro antitumor activities of 13 saframycins, including the potent antitumor component, saframycin A, were determined with the highly sensitive established cell line of L1210 mouse leukemia to investigate structure-activity relationships. Saframycins which lack the alpha-cyanoamine group or the alpha-carbinolamine group exhibited much lower ...
Katsuhiro Takahashi +4 more
openaire +4 more sources
Quantile Regression Neural Networks Based Prediction of Drug Activities [PDF]
, 2014 QSAR (quantitative structure-activity relationship) modeling is one of the well developed areas in drug development through computational chemistry. Similar molecules with just a slight variation in their structure can have quit different biological ...
El-Telbany, Mohammed E.
core +2 more sources
Molecular Oncology, EarlyView.Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda +3 more
wiley +1 more source
Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex
Journal of Future FoodsGlycoprotein complexes, a kind of structural biomolecules, are characterized by extensive functions, such as immunomodulatory and anti-inflammatory activities.
Yu Zhong +7 more
doaj
Molecules, 2017 In this study, we tested eight naturally-occurring flavonoids—three flavanones and five flavones—for their possible antibacterial properties against four Gram-positive and four Gram-negative bacteria.
Javier Echeverría +4 more
doaj +1 more source
Pattern recognition system based on support vector machines: HIV-1 integrase inhibitors application [PDF]
, 2013 Support Vector Machines (SVM) represent one of the most promising Machine Learning (ML) tools that can be applied to develop a predictive Quantitative Structure-Activity Relationship (QSAR) models using molecular descriptors.
Darnag, Rachid +2 more
core +1 more source
Structure activity relationship (SAR) studies of neurotoxin quinoline-derivatives [PDF]
, 2020 Structure activity relationship (SAR) studies are performed in order to identify the core structure that is responsible for the biological activity of an organic molecule.
Smeyne, Dylan
core +1 more source
Molecules, 2017 Polyphenols are plant-derived natural products with well-documented health benefits to human beings, such as antibacterial activities. However, the antibacterial activities of polyphenols under hyperglycemic conditions have been rarely studied, which ...
Yixi Xie +3 more
semanticscholar +1 more source