Results 81 to 90 of about 731,585 (310)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Neuropsychological function-brain structure relationships and stage of illness:An investigation into chronic and first-episode schizophrenia [PDF]

, 2008
Neuropsychological function-brain structure relationships may differ as a function of illness stage because of progressive brain matter loss through the course of schizophrenia.
Prernkumar, P, Corr, P J J, Kumari, V, Premkumar, P, Corr, Philip, Sharma, T, Fannon, D, Corr, PJ   +7 more
core   +1 more source

Relationships between structure and properties in commercial lead zirconate titanate (PZT) piezoceramics

Journal of Materiomics
Lead zirconate titanate (PZT) ceramics are the most widely used commercial piezoelectric ceramics. However, the relationships between structure and properties are still not completely clarified.
Xuyao Tang, Zimeng Hu, Vladimir Koval, Harry Baxter, Mirva Eriksson, Richard Whiteley, Krishnarjun Banerjee, Giuseppe Viola, Bin Yang, Haixue Yan   +9 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Investigating Relationships between the Crystal Structure and 31P Isotropic Chemical Shifts in Calcined Aluminophosphates [PDF]

, 2014
Solid-state NMR spectra have historically been assigned using simple relationships between NMR parameters, e.g., the isotropic chemical shift, and aspects of the local structure of the material in question, e.g., bond angles or lengths.
Daniel M. Dawson, Ashbrook, Sharon Elizabeth, Sharon E. Ashbrook, Dawson, Daniel McLean   +3 more
core   +1 more source

Mapping temperature-dependent energy-structure-property relationships for solid solutions of inorganic halide perovskites [PDF]

, 2020
Formation of solid solutions with complex compositions has been exhaustively adopted in materials research for improving the chemical and physical properties.
Yang, J ; https://orcid.org/, Jack, Yang
core   +2 more sources

Optimization of structural and poling strategies in piezoelectric elastomer composites for soft sensing applications

Materials & Design
Piezoelectric flexible sensors are emerging as key components in medical applications, offering unique electromechanical properties for various diagnostic and therapeutic purposes.
Tasnim Missaoui, Xavier P. Morelle, Minh Quyen Le, Pierre-Jean Cottinet, Jean-Fabien Capsal, Guilhem Rival   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Circumpapillary structure-function relationships with microperimetry and spectral domain optical coherence tomography in glaucoma: a pilot study [PDF]

, 2018
Yoshiyuki Kita,1 Gábor Holló,2 Akiko Murai,1 Ritsuko Kita,1 Tsunehiro Saito,1 Akito Hirakata1 1Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, Semmelweis University, Budapest ...
Holló G, Saito T, Kita R, Murai A, Hirakata A, Kita Y   +5 more
core