Results 31 to 40 of about 318,887 (260)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Redox properties of alkyl-substituted 4-aryl-2,4-dioxobutanoic acids [PDF]

Journal of the Serbian Chemical Society, 2017
Redox properties of a set of aryldiketo acids (ADKs), small organic molecules that comprise 2,4-dioxobutanoic acid moiety, were studied. Along with well-known HIV-1 integrase (IN) inhibition, ADKs exert widespread biological activities.
Cvijetić Ilija N., Verbić Tatjana Ž., Drakulić Branko J., Stanković Dalibor M., Juranić Ivan O., Manojlović Dragan D., Zloh Mire   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Direct prediction of inelastic neutron scattering spectra from the crystal structure

Machine Learning: Science and Technology, 2023
Inelastic neutron scattering (INS) is a powerful technique to study vibrational dynamics of materials with several unique advantages. However, analysis and interpretation of INS spectra often require advanced modeling that needs specialized computing ...
Yongqiang Cheng, Geoffrey Wu, Daniel M Pajerowski, Matthew B Stone, Andrei T Savici, Mingda Li, Anibal J Ramirez-Cuesta   +6 more
doaj   +1 more source

Towards structure–property–function relationships for eumelanin [PDF]

Soft Matter, 2006
We discuss recent progress towards the establishment of important structure-property-function relationships in eumelanins - key functional bio-macromolecular systems responsible for photo-protection and immune response in humans, and implicated in the development of melanoma skin cancer.
Meredith, P., Powell, B. J., Riesz, J., Nighswander-Rempel, S. P., Pederson, M. R., Moore, E. G.   +5 more
openaire   +5 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Micro-Structure Determines the Intrinsic Property Difference of Bio-Based Nitrogen-Doped Porous Carbon—A Case Study

Nanomaterials, 2020
Biomass-derived porous carbon materials have drawn considerable attention due to their natural abundance and low cost. In this work, nitrogen-doped porous carbons with high nitrogen content and large surface areas were designed and prepared from ...
Yingfang Jiang, Yanxia Liu, Yagang Zhang, Yidan Chen, Xingjie Zan   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Spatial heterogeneity as the structure feature for structure–property relationship of metallic glasses

Nature Communications, 2018
Directly relating the mechanical properties of metallic glasses to their atomic structure remains a challenge. Here, the authors use high resolution microscopy to show many mechanical properties of metallic glasses depend on a single structural parameter,
Fan Zhu, Shuangxi Song, Kolan Madhav Reddy, Akihiko Hirata, Mingwei Chen   +4 more
doaj   +1 more source

Graphene Oxides Derivatives Prepared by an Electrochemical Approach: Correlation between Structure and Properties

Nanomaterials, 2020
Graphene oxide (GO) can be defined as a single monolayer of graphite with oxygen-containing functionalities such as epoxides, alcohols, and carboxylic acids.
Carlos Sainz-Urruela, Soledad Vera-López, María Paz San Andrés, Ana M. Díez-Pascual   +3 more
doaj   +1 more source