Results 141 to 150 of about 8,160,938 (248)

CCDC 203237: Experimental Crystal Structure Determination

open access: green, 2014
Orson L. Sydora   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

CCDC 1471318: Experimental Crystal Structure Determination

open access: green, 2017
Daming Zheng   +5 more
openalex   +1 more source

Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O 2 incorporation by a heme-containing dioxygenase [PDF]

open access: bronze, 2006
Hiroshi Sugimoto   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

CCDC 1567314: Experimental Crystal Structure Determination

open access: green, 2017
Fang Ma   +5 more
openalex   +1 more source

Home - About - Disclaimer - Privacy