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Synthetic Retinoids: Structure–Activity Relationships
Chemistry – A European Journal, 2009AbstractRetinoid signalling pathways are involved in numerous processes in cells, particularly those mediating differentiation and apoptosis. The endogenous ligands that bind to the retinoid receptors, namely all‐trans‐retinoic acid (ATRA) and 9‐cis‐retinoic acid, are prone to double‐bond isomerisation and to oxidation by metabolic enzymes, which can ...
Jonathan H, Barnard +4 more
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Structure-Activity Relationships
2020The objective of structure-activity relationship studies is to define as precisely as possible the limits of variation in the structure of a chemical moiety that are consistent with the production of a specific biological effect and the ways in which alterations in the environment of this moiety and overall properties of the molecule influence potency.
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Structure-activity relationships among mycotoxins
Chemico-Biological Interactions, 1989Relationships between structural features and biological effects of mycotoxins are reviewed. Structure-activity relationships are characterized at the molecular, subcellular, cellular, or supracellular level. Major chemical and physicochemical factors responsible for bioactivity of mycotoxins are stressed.
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Structure-Activity Relationships
1999Estrogens and antiestrogens are understood to exert their hormonal action after binding to the estrogen receptor (ER), a member of the nuclear receptor superfamily. Until recently, the knowledge of the shape of the full-length ER and the structure of the hormone-binding domain has been rather vague, due to the lack of cristallographie data. Information
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Structure-Activity Relationships in Glucocorticoids
1979Meaningful answers to the question of the relationship between glucocorticoid structure and activity have emerged. Structural change has predictable effects on susceptibility to the action of metabolizing enzymes, on receptor affinity, and on intrinsic activity. These effects are, in principle, amenable to mathematical modeling techniques.
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Dopamine agonists: structure-activity relationships
1985In the several years since Blaschko [1] first suggested that dopamine might be a neurotransmitter substance, many chemical compounds have been found to possess dopamine-like actions. This review surveys classes of structures for which putative dopaminergic agonism has been reported, and cites structure-activity correlations.
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American Cancer Society nutrition and physical activity guideline for cancer survivors
Ca-A Cancer Journal for Clinicians, 2022Cheryl L Rock +2 more
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American Cancer Society guideline for diet and physical activity for cancer prevention
Ca-A Cancer Journal for Clinicians, 2020Cheryl L Rock +2 more
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