Results 201 to 210 of about 2,034,226 (308)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Analyzing aptamer structure and interactions: in silico modelling and instrumental methods. [PDF]

Biophys Rev
Malysheva DO, Dymova MA, Richter VA.
europepmc   +1 more source

Fluid-structure-acoustic interactions in an ex vivo porcine phonation model. [PDF]

J Acoust Soc Am, 2021
Semmler M, Berry DA, Schützenberger A, Döllinger M.   +3 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Unravelling structure-function interactions between fluorinated heparan sulfate mimetics and signaling proteins. [PDF]

RSC Chem Biol
Mahida V, Raigawali R, González P, Gimeno A, Leviatan Ben-Arye S, Anand S, Mardhekar S, Jiménez-Barbero J, Padler-Karavani V, Kikkeri R.   +9 more
europepmc   +1 more source

Straightforward Regio- and Diastereoselective Synthesis, Molecular Structure, Intermolecular Interactions and Mechanistic Study of Spirooxindole-Engrafted Rhodanine Analogs. [PDF]

Molecules, 2021
Barakat A, Haukka M, Soliman SM, Ali M, Al-Majid AM, El-Faham A, Domingo LR.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Structure and Interactions in 1:2 K⁺-Crown Ether Complexes via Gas-Phase Cold UV and IR Spectroscopy. [PDF]

J Phys Chem Lett
Inokuchi Y, Rizzo TR.
europepmc   +1 more source

Modeling the Structure and Interactions of Intrinsically Disordered Peptides with Multiple Replica, Metadynamics-Based Sampling Methods and Force-Field Combinations. [PDF]

J Chem Theory Comput, 2022
Li L, Casalini T, Arosio P, Salvalaglio M.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source