Results 181 to 190 of about 2,034,226 (308)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

GPR17 in Glioblastoma: Structure, Ligand Interactions, and Therapeutic Targeting. [PDF]

ACS Omega
Satyanarayana R, Chaitanya SS, Suresh Kumar I, Thiyagarajan R, Chandrabose S, Abass KS, Konda Mani S, Thirunavukarasou A, Kandhavelu M.   +8 more
europepmc   +1 more source

Process-Structure-Formulation Interactions for Enhanced Sodium Ion Battery Development: A Review. [PDF]

Chemphyschem, 2022
Sawhney MA, Wahid M, Muhkerjee S, Griffin R, Roberts A, Ogale S, Baker J.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nonlinear drivers and spatial heterogeneity of urban heat islands in lake-dense regions across ecological stress-structure-service interactions. [PDF]

Sci Rep
Xiong S, Yang F, Fan H.
europepmc   +1 more source

Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. [PDF]

J Virol, 2022
Mietzsch M, Hull JA, Makal VE, Jimenez Ybargollin A, Yu JC, McKissock K, Bennett A, Penzes J, Lins-Austin B, Yu Q, Chipman P, Bhattacharya N, Sousa D, Strugatsky D, Tijssen P, McKenna R, Agbandje-McKenna M.   +16 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Study of the inhibition mechanism of HIV-1 integrase by diketoacids molecules

Journal of Virus Eradication, 2016
Léa El Khoury, Zeina Hobaika, Krystel El Hage, Serge Fermandjian, Jean-Philip Piquemal, Nohad Gresh, Richard G. Maroun   +6 more
doaj   +1 more source

Unveiling the structure and interactions of silicene grown on MoS₂: insights from hybrid molecular dynamics simulations. [PDF]

Acta Crystallogr B Struct Sci Cryst Eng Mater
Barboza AM, Aliaga LCR, de Faria DF, Bastos IN.   +3 more
europepmc   +1 more source

New polymorphic phase of arachidic acid crystal: structure, intermolecular interactions, low-temperature stability and Raman spectroscopy combined with DFT calculations. [PDF]

RSC Adv, 2023
Cardoso LMB, de Oliveira Neto JG, Saraiva GD, Leite FF, Ayala AP, Dos Santos AO, de Sousa FF.   +6 more
europepmc   +1 more source