Results 171 to 180 of about 2,034,226 (308)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The thyrotropin receptor structure and interactions with autoantibodies. [PDF]

Eur Thyroid J
Rees Smith B, Núñez Miguel R, Sanders J.   +2 more
europepmc   +1 more source

Comparison and interpretation of freshwater bacterial structure and interactions with organic to nutrient imbalances in restored wetlands. [PDF]

Front Microbiol, 2022
Zheng F, Zhang T, Yin S, Qin G, Chen J, Zhang J, Zhao D, Leng X, An S, Xia L.   +9 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Eco-friendly starch-nanocellulose bio-nanocomposite films with improved structure-property interactions. [PDF]

Nanoscale Adv
Reza MS, Tutul MSI, Khandaker T, Paul C, Minhaz-Ul Haque M, Hossain MS.   +5 more
europepmc   +1 more source

The Story of the Fibrin(ogen) αC-Domains: Evolution of Our View on Their Structure and Interactions. [PDF]

Thromb Haemost, 2022
Medved L, Weisel JW.
europepmc   +1 more source

Effects of social interactions on scientists' productivity [PDF]

Recent economic research has focused on the economic effects of the social environment. In the economic literature, important phenomena are considered, at least in part, as results of the individual's social environment.
Capitanio, Fabian, Papagni, Erasmo, Carillo, Maria Rosaria   +2 more
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Social Structure and Interactions Differentially Shape Aerotolerant and Anaerobic Gut Microbiomes in a Cooperative Breeding Species. [PDF]

Mol Ecol
Lee CZ, Worsley SF, Burke T, Komdeur J, Hildebrand F, Dugdale HL, Richardson DS.   +6 more
europepmc   +1 more source

The Antibacterial Type VII Secretion System of Bacillus subtilis: Structure and Interactions of the Pseudokinase YukC/EssB. [PDF]

mBio, 2022
Tassinari M, Doan T, Bellinzoni M, Chabalier M, Ben-Assaya M, Martinez M, Gaday Q, Alzari PM, Cascales E, Fronzes R, Gubellini F.   +10 more
europepmc   +1 more source