Results 81 to 90 of about 1,344,305 (317)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Seasonal variation in structure and function of gut microbiota in Pomacea canaliculata

Ecology and Evolution, 2022
Gut microbiota is associated with host health and its environmental adaption, influenced by seasonal variation. Pomacea canaliculata is one of the world's 100 worst invasive alien species.
Shuxian Li, Zijin Qian, Jiani Yang, Youfu Lin, Hong Li, Lian Chen   +5 more
doaj   +1 more source

Patterns of somatic structural variation in human cancer genomes

, 2020
A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes1–7.
PCAWG Structural Variation Working Group, PCAWG Consortium   +1 more
core   +1 more source

Variations in urban population structure [PDF]

Demography, 1964
Hasta ahara no se ha prestado atencion suficiente, en materia de investigacion, al estudio sistematico y cuantitativo de la persisiencia y las variaciones en el tiempo de las caracteristicas espaciales de la distribucion y composicion de la poblacion. Utilizando datos de distritos censales para 1940 y 1960 en dos ciudades (Seatle y Rochester), el autor
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Insights into the genome structure and copy-number variation of Eimeria tenella

BMC Genomics, 2012
Background Eimeria is a genus of parasites in the same phylum (Apicomplexa) as human parasites such as Toxoplasma, Cryptosporidium and the malaria parasite Plasmodium.
Lim Lik-Sin, Tay Yea-Ling, Alias Halimah, Wan Kiew-Lian, Dear Paul H   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Large-scale variation in combined impacts of canopy loss and disturbance on community structure and ecosystem functioning. [PDF]

, 2013
Ecosystems are under pressure from multiple human disturbances whose impact may vary depending on environmental context. We experimentally evaluated variation in the separate and combined effects of the loss of a key functional group (canopy algae ...
Griffin Migné, JN, Sousa Pinto, I, Aspden, Rebecca, Bevilacqua, Stanislao, Fraschetti, Simonetta, Noel, Laure M-L J., Emma Defew, Sophie K Nicol, Irvine Davidson, Aspden R, Molis M, Valdivia Nelson, Lisandro Benedetti-Cecchi, Nicol Sophie K., Jenkins Stuart R., Kotta, J, Kristjan Herk?l, Griffin JN, Noël LM-LJ, Herkuel, Kristjan, Kotta Jonne, Davidson, I, Cusson, M, Golléty C, Rebecca Aspden, Kristjan Herkül, Herkül K, Dominique Davoult, Defew, Emma, Bevilacqua Stanislao, Laure M-L J Noël, Noël, Laure M. -L. J., Griffin, John N., Sousa Pinto I, Davidson Irvine, Jonne Kotta, Noël LM LJ, Herkül Kristjan, Noël, LM-LJ, Benedetti-Cecchi, L, Pinto, Isabel Sousa, Jenkins, SR, Bulleri, F, Benedetti-Cecchi Lisandro, Herkül, K, Valdivia N, Cusson M, Cusson Mathieu, Aspden Rebecca, Jenkins, Stuart R., Golléty Claire, Benedetti-Cecchi L, Claire Golléty, Nelson Valdivia, Cusson, Mathieu, Davidson, Irvine, Laure M. L. J. No?l, Molis, Markus, Stuart R Jenkins, Crowe, Tasman P., Aline Mign?, Bulleri, Fabio, Bulleri Fabio, Claire Goll?ty, BENEDETTI CECCHI, LISANDRO, Stanislao Bevilacqua, Migné, A, Pinto Isabel Sousa, Defew Emma, Crowe, T, Stefano Vaselli, Stuart R. Jenkins, Isabel Sousa Pinto, Jenkins SR, Noël Laure M-L J., Bulleri F, Davoult Dominique, Nicol, Sophie K., Arenas Francisco, Davoult, Dominique, Migné Aline, Vaselli, Stefano, Francisco Arenas, Migne, Aline, Vaselli S, Aspden, R, Mathieu Cusson, Fabio Bulleri, Davidson I, Kotta J, Migné A, Golléty, C, Bevilacqua S, Sophie K. Nicol, Markus Molis, Vaselli Stefano, Nicol, SK, Aline Migné, Tasman P. Crowe, John N. Griffin, Fraschetti S, Herkül, Kristjan, Simonetta Fraschetti, Molis Markus, Crowe TP, Nicol SK, Davoult, D, Arenas, Francisco, Benedetti Cecchi L, Arenas, F, Arenas F, Tasman P Crowe, Crowe Tasman P., Defew, E, Davoult D, Bevilacqua, S, Griffin John N., Kotta, Jonne, Fraschetti Simonetta, John Griffin, Defew E, Benedetti-Cecchi, Lisandro, Valdivia, Nelson, Fraschetti, S, John N Griffin, Gollety, Claire   +125 more
core   +1 more source

Structural and genomic variation in preterm birth [PDF]

Pediatric Research, 2016
Runs of homozygosity (ROH) are consecutive homozygous genotypes, which may result from population inbreeding or consanguineous marriages. ROH enhance the expression of recessive traits.We mapped ROH in a case control study of women delivering at term compared with women delivering at or before 34 wk gestation. Gene sets known to be important in risk of
Uzun, Alper, Sahin, Yavuz, Schuster, Jessica S., Zheng, Xiaojing, Ryckman, Kelli, Feingold, Eleanor, Padbury, James   +6 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source