Results 51 to 60 of about 121,928 (262)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
NEW DIORGANOCHALCOGEN COMPOUNDS BASED ON THE 2-(Me₂NCH₂)C₆H₄ GROUP
Studia Universitatis Babes-Bolyai Chemia, 2016 Heteroleptic diorganochalcogen compounds of type R[2-(Me2NCH2)C6H4]E [R = (phtz)CH2, E = Se (1), S (2); R = (4-Cl-phtz)CH2, E = S (3); R = (pz)CH2CH2, E = Se (4)] were prepared by reacting 2-(Me2NCH2)C6H4ELi with the appropriate organic halide in a 1:1 ...
Bianca DANCIU +5 more
doaj
Molecules, 2018 Roussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp.
Chayanard Phukhamsakda +4 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Indonesian Journal of Chemistry, 2010 Isolation and structure elucidation of two resveratrols dimer, namely balanocarpol (1) and heimiol A (2) from stem bark of Hopea mengarawan had been done.
Sri Atun +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Natural Products and BioprospectingBletilla striata is highly regarded in traditional Chinese medicine and has also gained widespread attention as a valuable medicinal plant resource. However, the molecular composition and bioactive potential of its polysaccharides present a significant ...
Xuan Li +8 more
doaj +1 more source