Results 171 to 180 of about 3,832,797 (315)

Genetic Land - Modeling land use change using evolutionary algorithms [PDF]

Future land use configurations provide valuable knowledge for policy makers and economic agents, especially under expected environmental changes such as decreasing rainfall or increasing temperatures, or scenarios of policy guidance such as carbon ...
Maria Julia Seixas, Fernando Lobo, Pedro Lourenço, Paulo Condado, João Pedro Nunes   +4 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Homo- and Heteroleptic Silylstannylenes: Synthesis, Structure and Use as Precursors to Bimetallic Compounds. [PDF]

Organometallics
Murray AJ, Wales LL, Dietz M, Poland EM, McManus C, Crumpton AE, Struijs JJC, Aldridge S.   +7 more
europepmc   +1 more source

The use of polyhedra for Building Structures

, 1982
Planning to use uniform polyhedra as elementary units in standardized construction systems, the Building Technology Research Group in Delft has found it necessary to study the metric properties of these polyhedra in detail. Computer graphics techniques were employed. Applications include emergency housing kits.
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Computer use and the U.S. wage distribution, 1984-2003 [PDF]

Given past estimates of wage increases associated with workplace computer use and higher usage rates among more skilled workers, the diffusion of computers has been interpreted as a mechanism for skill-biased technological change and consequent widening ...
Robert G. Valletta
core  

Carbon uptake dynamics of cement-based materials: Linking market structure, material use, and the carbon cycle. [PDF]

Proc Natl Acad Sci U S A
AzariJafari H, Manav IB, Rahimi M, Moore E, Huet B, Levy C, Kirchain R.   +6 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Board structure, Ownership structure, and Firm performance : Evidence from Banking [PDF]

This paper examines the interrelations among five ownership and board characteristics in a sample of 260 bank and savings-and-loan holding companies. These governance characteristics, designed to reduce agency problems between shareholders and managers ...
Mohamed Belkhir
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source