How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases. [PDF]
Front Cell Dev Biol, 2021 Wang K, Meng X, Guo Z.
europepmc +1 more source
Effect of Oxygen-Doping in Ferroelectric Wurtzite-type Al0.73Sc0.27N [PDF]
BIO Web of ConferencesIslam Redwanul +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Synthesis and Structure of Adamantane-Containing Phosphazenes
, 2016 Synthesis and Structure of Adamantane-Containing ...
Karyn B. Visscher (2956770) +3 more
core +1 more source
Factor VII Activating Protease (FSAP) and Its Importance in Hemostasis-Part I: FSAP Structure, Synthesis and Activity Regulation: A Narrative Review. [PDF]
Int J Mol Sci, 2023 Kwiatkowska I +5 more
europepmc +1 more source
Low-temperature ALD-grown HfS2 for wafer-scale memristive device integration
Discover MaterialsUnlocking the potential of 2D materials like transition metal dichalcogenides (TMDCs) requires controllable, CMOS-compatible deposition techniques. Here, we report a wafer-scale, low-temperature atomic layer deposition (ALD) process for hafnium disulfide
Anna Linkenheil +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source