Results 141 to 150 of about 1,114,115 (315)
Speech act theory, discourse structure and indirect speech [PDF]
, 1991 Speech Act Theory is concerned with the ways in which language can be used. It originated with Austin, but was developed by Searle. The theories of Austin and Searle are described and several problem areas are identified.
Smith, Peter Wilfred Hesling
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
An Algebraic Theory of Structured Objects
Notre Dame Journal of Formal Logic, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Applied SciencesIn contemporary construction, the prevalence of vibration serviceability issues in lightweight and slender structures has become increasingly common, owing to advancements in building materials and construction methods.
Emiliano Pereira +3 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Revealing the mystery of the double charm tetraquark in pp collision
European Physical Journal C: Particles and FieldsA novel approach is proposed to probe the nature of the double charm tetraquark through the prompt production asymmetry between $$T_{\bar{c}\bar{c}}^-$$ T c ¯ c ¯ - and $$T_{cc}^+$$ T cc + in pp collisions.
Xue-Li Hua +5 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
eminus — Pythonic electronic structure theory
SoftwareXIn current electronic structure research endeavors such as warm dense matter or machine learning applications, efficient development necessitates non-monolithic software, providing an extendable and flexible interface.
Wanja Timm Schulze +3 more
doaj +1 more source