Results 101 to 110 of about 3,924,108 (319)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Raw diffraction data for structure of SARS-CoV-2 main protease with PCM-0102287 (ID: mpro-x0830 / PDB: 5REX)

, 2020
David Aragão, J. Brandão-Neto, Anna Carbery, Adam Crawshaw, Alexandre Dias, A. Douangamath, Louise Dunnett, D. Fearon, Ralf Flaig, Paul Gehrtz, Dave Hall, T. Krojer, Nir London, Petra Lukacik, Marco Mazzorana, Katherine McAuley, David Owen, A.J. Powell, Rambabu Reddi, Efrat Resnick, R. Skyner, Matt Snee, Claire Strain‐Damerell, David I. Stuart, F. von Delft, Martin Walsh, Conor Wild, Mark Williams, Graeme Winter   +28 more
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Raw diffraction data for structure of SARS-CoV-2 main protease with Z1367324110 (ID: mpro-x0195 / PDB: 5R81)

, 2020
David Aragão, J. Brandão-Neto, Anna Carbery, Adam Crawshaw, Alexandre Dias, A. Douangamath, Louise Dunnett, D. Fearon, Ralf Flaig, Paul Gehrtz, Dave Hall, T. Krojer, Nir London, Petra Lukacik, Marco Mazzorana, Katherine McAuley, David Owen, A.J. Powell, Rambabu Reddi, Efrat Resnick, R. Skyner, Matt Snee, Claire Strain‐Damerell, David I. Stuart, F. von Delft, Martin Walsh, Conor Wild, Mark Williams, Graeme Winter   +28 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Big data acquisition for underground infrastructure condition assessment

Data-Centric Engineering
The condition assessment of underground infrastructure (UI) is critical for maintaining the safety, functionality, and longevity of subsurface assets like tunnels and pipelines.
Chao Wang, Zhipeng Xiao, Yixian Wang, Fei Wang, Zili Li   +4 more
doaj   +1 more source

Raw diffraction data for structure of SARS-CoV-2 main protease with Z1741970824 (ID: mpro-x0995 / PDB: 5RF3)

, 2020
David Aragão, J. Brandão-Neto, Anna Carbery, Adam Crawshaw, Alexandre Dias, A. Douangamath, Louise Dunnett, D. Fearon, Ralf Flaig, Paul Gehrtz, Dave Hall, T. Krojer, Nir London, Petra Lukacik, Marco Mazzorana, Katherine McAuley, David Owen, A.J. Powell, Rambabu Reddi, Efrat Resnick, R. Skyner, Matt Snee, Claire Strain‐Damerell, David I. Stuart, F. von Delft, Martin Walsh, Conor Wild, Mark Williams, Graeme Winter   +28 more
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source