Results 211 to 220 of about 3,924,108 (319)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Small language models enable rapid and accurate extraction of structured data from unstructured text: An example with plants and their specialized metabolites. [PDF]

Quant Plant Biol
Busta L, Oyler AR.
europepmc   +1 more source

Analysis of Structured Data in Biomedicine Using Soft Computing Techniques and Computational Analysis.

Comput Intell Neurosci, 2022
Wu Y, Rahman MH.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Petri graph neural networks advance learning higher order multimodal complex interactions in graph structured data. [PDF]

Sci Rep
Ademovic Tahirovic A, Angeli D, Tahirovic A, Strbac G.   +3 more
europepmc   +1 more source

Validation of the IPSL Venus GCM thermal structure with VIRTIS data

, 2019
Pietro Scarica, Itziar Gárate-López, S. Lebonnois, G. Piccioni, D. Grassi, A. Migliorini   +5 more
openalex   +1 more source

Bone quality analysis at implant sites through surgical data and trabecular bone structure parameters obtained on Cone Beam Computed Tomography images

, 2020
Jéssica Rabelo Mina Zambrana
openalex   +1 more source

X-Ray diffraction data relating to protein structure PDB ID: 6RYG

, 2019
A.K. Shrive, Trevor J. Greenhough
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source