Results 151 to 160 of about 443,266 (330)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Poverty and struggle against poverty as a global issue and NGO`s: A specific case study of Turkey-related Doctors Worldwide

open access: yes, 2021
Poverty is a global issue the world is confronting today. This study aims to show the ways of struggle against poverty which is a big problem of the world?s agenda. NGO?s have a big role in the struggle against poverty and therefore this thesis gives particular importance of NGO?s in relation with alleviation strategies.The effect of globalization on ...
openaire   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

The social programs of struggle against the extreme poverty in the province of Leoncio Prado – 2005

open access: yes, 2009
El presente estudio tiene como ámbito geográfico la Provincia de Leoncio Prado en la Región Huánuco. El análisis estuvo referido a los programas sociales que tienen como misión contribuir a elevar el nivel alimentario y nutricional de grupos en situación de pobreza extrema, focalizando como primera prioridad a niños de cero a 7 años, madres gestantes y
Villaizán y Huerto, Jorge   +3 more
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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