Results 61 to 70 of about 8,989,970 (293)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Development of student-centred language learning environment [PDF]
2017 9th International Conference on Information Technology and Electrical Engineering (ICITEE), 2017 Student-centred learning is considered one of the most significant pedagogical point of views. Active student participation and connecting learning processes to real world situations are one of the defining properties of the approach. A student-centred learning environment offers students the tools for content production and management with interactive
Jarmo Seppala, Kuniaki Yajima
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Subject centred learning enables effective tertiary teaching [PDF]
, 2013 The measurement of quality in tertiary teaching is a contested concept and different definitions emerge in relation to shifting social, economic and political contexts and different stakeholders. We suggest that following the work of Parker Palmer (1998)
Morrison-Saunders, A., Hobson, J.
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Learning in the 21st century: Empowering student-centred practices through curriculum integration [PDF]
, 2014 The New Zealand Curriculum [NZC] provides a framework for schools to design and implement the curriculum at three levels: Nationally, school- wide, and in the classroom (Ministry of Education [MoE], 2007).
Morgan, Jason
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Journal of Technology and Science Education, 2017 This paper presents a blended-learning strategy for improving the teaching method applied in the laboratory subject Manufacturing Technologies. The teaching method has been changed from a predominantly teacher-centred to an active learning system with a ...
Albert Fabregat-Sanjuan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Management of a student centred online environment [PDF]
, 2000 With the development of new undergraduate degree programs within Murdoch University's School of Engineering, the decision was made to offer courses, as much as practical, online.
Roy, G.G., Armarego, J.
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