Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Role of Personal Values and Student Achievement in Academic Dishonesty. [PDF]
Front Psychol, 2019 Koscielniak M, Bojanowska A.
europepmc +1 more source
فعالية إستراتيجيات التعلم النشط في تحسين التحصيل الأكاديمي ومستوى الطموح الأكاديمي لدى طالبات قسم رياض الأطفال The effectiveness of active learning strategies in improving academic achievement and the level of academic ambition among kindergarten students [PDF]
أمانى خميس محمد عثمان
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Voucher Pathways and Student Achievement in Indiana's Choice Scholarship Program. [PDF]
RSF, 2019 Austin M, Waddington RJ, Berends M.
europepmc +1 more source
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Correlation of Emotional Intelligence, Creativity, and Academic Achievement with the Mediation of Psychological Capital in Sixth Grade Male Elementary Students [PDF]
Parvin Salarichine, Ali Fazeli Varzane
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source