Results 231 to 240 of about 2,548,588 (297)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Use of a Standardized Patient Team Experience to Improve Student Interprofessional Collaboration and Teamwork. [PDF]

MedEdPORTAL
Griffith JL, Burlis T, Gershwin K, Hanson J, Milton LE, Moquin R, Somerville E, Tiemeier AM, Hageman H.   +8 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Social Return on Investment Evaluation of the Expansion of an Allied Health Student Training Programme in Rural Australia. [PDF]

Aust J Rural Health
French L, Lander C, Green E, Nott M, Anderson G, Brusco NK.   +5 more
europepmc   +1 more source

Feasibility of peer-assisted interprofessional learning between pharmacy and exercise physiology students in providing integrated care. [PDF]

BMC Med Educ
Zhang W, Du Q, Zhao Y, Jiang LY, Jing ZQ.   +4 more
europepmc   +1 more source

Exploring an activity-enhanced scaffolding for knowledge structure representing: could the knowledge-activity connection promote students' online learning experience in AI curriculum? [PDF]

Front Psychol
Wan H, Que R, Cheng L, Li S, Wang Q, Liu J.   +5 more
europepmc   +1 more source

Enhancing medical students comprehension through active learning: implementing the jigsaw method to improve engagement. [PDF]

Front Med (Lausanne)
Begum G, Goud BKM, Marakala V, Hamad NA, Elizabeth S, Khan FH, Agarwal A, Khattak O, Fareed MA, Alshammari KF, Desai VB, Chaudhary FA.   +11 more
europepmc   +1 more source

Prediction of neural activity in connectome-constrained recurrent networks. [PDF]

Nat Neurosci
Beiran M, Litwin-Kumar A.
europepmc   +1 more source