Results 231 to 240 of about 17,261,047 (284)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

President's Student Council, Issue 5, August 2015 [PDF]

, 2015
Naval Postgraduate School, Student Council   +1 more
core  

Train-the-Trainer Evaluation of Technology-Enhanced Learning in Preservice Midwifery Education in Nigeria: Qualitative Descriptive Study. [PDF]

JMIR Nurs
Garti I, Shikpup N, Tonto O, Gray M, Abdul HM, Ladan AM.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Anchoring links in Chinese pre-service teachers' role beliefs about typically developing students and those with intellectual and developmental disabilities: a metaphorical analysis. [PDF]

Front Psychol
Xin W, Wang X, Zhang Z, Cao L.
europepmc   +1 more source

President's Student Council, Issue 6, June 2015 [PDF]

, 2015
Naval Postgraduate School, Student Council   +1 more
core  

Tailoring pedagogical methods to enhance student engagement through a student-faculty partnership in an undergraduate immunology course. [PDF]

J Microbiol Biol Educ
Mujtaba MG, Justiniano D.
europepmc   +1 more source

E-health literacy and health system distrust: exploring a nonlinear association in a cross-sectional study. [PDF]

Rev Assoc Med Bras (1992)
Come O, Bas İY, Mevsim V.
europepmc   +1 more source

Assessing the Evolving the Culture of Biology program through the lens of the Teacher-Centered Systemic Reform model. [PDF]

J Microbiol Biol Educ
Shihadih DS, Runkel Baez E, Asgari M, Berl J, Chouinard AJ, Gutzler SJ, Heinrich KK, Riordan E, Lee SW, Shortlidge EE.   +9 more
europepmc   +1 more source

Profiles of gifted students through the eyes of their teachers: identifying students at risk for underachievement. [PDF]

Front Child Adolesc Psychiatry
van der Weijden FA, Hornstra L, Kroesbergen EH.   +2 more
europepmc   +1 more source