Results 81 to 90 of about 2,217,966 (312)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Student SuccessTransition pedagogy is a whole-of-institution approach for supporting learning across diverse student cohorts through intentional, integrated (co-)curricular design.
Ryan Naylor
doaj +1 more source
Early Grade Retention and Student Success: Evidence From Los Angeles [PDF]
, 2011 Analyzes risk factors of retention through third grade in the L.A. Unified School District, including age, gender, race/ethnicity, family income, and English learner status; retention's effectiveness in improving grade-level skills; and educators ...
Jill S. Cannon, Stephen Lipscomb
core
Identity, Speech, and Equality [PDF]
, 1993 My experience as a litigator tells me that the First Amendment as provided the most reliable path to success of any of the doctrinal claims utilized by lesbian and gay rights lawyers.
Hunter, Nan D.
core +2 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Promoting Student Success in Community Colleges by Increasing Support Services [PDF]
, 2006 Recommends state policies to improve community college students' retention and completion rates through enhanced tutoring, counseling, and other supports, as well as alternative instructional models that allow working adults to learn in flexible ...
Brandon Roberts, Deborah Povich
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Student SuccessA Transition Pedagogy framework acknowledges students’ transition into university from diverse backgrounds, with varied preparedness for studying at university.
Kelly Linden +2 more
doaj +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source