Results 131 to 140 of about 15,365,324 (324)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

MicroRNA-21 expression as a novel diagnostic and prognostic biomarker in oral cancer: A narrative review

Indonesian Journal of Dental Medicine
Background: Oral cancer is a life-threatening disease that has 377.713 new cases every year and 60% of the 5-year overall survival rate globally. Approximately 84–97% of oral cancer arises from squamous cells, categorized as oral squamous cell carcinoma (
Yasminia Sambac Shofie Putri Llahfi, Anis Fatimah Zafar, Astrid Faradia ZV, Imelda Prisca Pandora, Alfonsus Sindhu SD, Muhammad Rafi NA, Salma Putri Widyanti, Emmanuel Andrew, Salsabilla Eliya A, Aliyya Alfisaida, Malika Qadira R, Aimmatur Rodhiyah B, Puspita Ramadhani, Ratri Indriani, Achmad Faishal Salim, Ciptantyo Septyan A, Alfin Rachmad C, Amirah Mujahidah, Sisca Meida Wati   +18 more
doaj   +1 more source

Developing an English for Academic Purposes Course for L2 Graduate Students in the Sciences

, 2020
Jennifer E. Douglas
openalex   +1 more source

Race, Geography, and School Choice Policy: A Critical Analysis of Detroit Students’ Suburban School Choices [PDF]

, 2022
Jeremy Singer, Sarah Winchell Lenhoff
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Improving Students' Skill to Write Islamic Historical Texts Through Dicstom Technique, the Trial Web Shift Design, and Engagement Strategy at Stai Bumi Silampari Lubuklinggau [PDF]

, 2017
This study aims to find the ability of third semester students, Prodi PAI (Islamic Religious Education) in writing texts of Islamic history in English. Students are taught 3 ways to write; (1) Dicstom, (2) Web Shift Trial, (3) Engagement, and (4) without
Helandri, J. (Joni)
core  

Student participation in university administration: factors, approaches and impact [PDF]

, 2021
Md. Shahabul Haque, Abdulghani Muthanna, Monira Sultana   +2 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source