Results 171 to 180 of about 87,206 (244)

Bridging Chemical Literature and Molecular Graphs: LLM‐Augmented Enantioselectivity Prediction for Iridium‐Catalyzed Asymmetric C–H Borylation

Advanced Science, EarlyView.
A machine‐learning framework for asymmetric C–H borylation bridges multi‐entity 3D molecular graphs and chemical literature. Atom‐resolved mechanistic annotations extracted by large language models augment three‐component graph encoding of catalyst, substrate, and product. The model predicts enantioselectivity with high accuracy on unseen scaffolds and
Zhe Wang, Baohua Zhang, Yi Isaac Yang, Yuan Yao, Yinwu Li   +4 more
wiley   +1 more source

"They can smell the 'short-termness' on you". Student learning and sense of belonging in the Arctic. [PDF]

Int J Qual Stud Health Well-being
Sæle RG, Borch KB, Borch I.
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Strengthening Partnerships in School-Based Substance Use Prevention and Intervention for Adolescents. [PDF]

J Sch Health
Casella J, Goodwin AKB, Lever N, Schaeffer CM.   +3 more
europepmc   +1 more source

Foundation Model‐Enabled Pathology‐Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study

Advanced Science, EarlyView.
PIVOT uses pathology‐derived morphologic and vascular representations from postoperative H&E and CD34 whole‐slide images to guide model development, while clinical inference requires only preoperative multiparametric MRI. Across five centers, PIVOT enabled accurate preoperative assessment of vessels encapsulating tumor clusters, stratified patients by ...
Zhehan Shen, Wanmin Liu, Xiaoming Li, Wenjie Zou, Yiman Li, Jie Yuan, Yasen Yimit, Shihang Wang, Linhao Qu, Hui Dong, Wei Chen, Ningyang Jia, Peijun Wang   +12 more
wiley   +1 more source

Information, Motivation, and Behavioral Skills Needs for Sexual Risk Prevention Among Early Adolescents in Thailand: A Qualitative Study. [PDF]

J Multidiscip Healthc
Deejuthamanee R, Maneesriwongul W, Patoomwan A, Granger J, Butsing N.   +4 more
europepmc   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

These children can become independent thanks to artificial intelligence! - A qualitative analysis of pre‑service teachers' views on the use of artificial intelligence in special education. [PDF]

PLoS One
Cotuk Yucel H, Kaya A, Arslan M.
europepmc   +1 more source

LigHTS: Biomimetic Hydrogel Photo‐Fabrication for Imaging‐Based Ultra‐High‐Throughput Screening

Advanced Science, EarlyView.
LigHTS removes a key bottleneck for ultra‐high‐throughput screening (UHTS) by enabling biomimetic hydrogel microenvironments to be manufactured directly in standard multiwell plates. A single, collimated UV exposure with formulation‐tuned light penetration patterns an entire plate with UHTS‐grade uniformity (<20% CV), producing structured GelMA films ...
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini   +7 more
wiley   +1 more source