Results 141 to 150 of about 7,585,042 (317)

The impact of education on economic growth: The case of Malaysia [PDF]

open access: yes, 2007
This paper studies the relationship between education and economic growth in Malaysia. We examine the relationship between educational variables and gross domestic product (GDP).
Abdul Latif, Nurul Wahilah   +1 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Transitions to Long-Term Care for People Living with Dementia: Social Death and Social (Dis) Connections

open access: yesNursing Reports
Background/objectives: Dementia is the most common cause for long-term care placement for people over the age of 65 years. The decision and the transition are often very difficult for families and the type and timing of effective support not well ...
Veronika Williams   +2 more
doaj   +1 more source

Review Essay: Arthur M. Schlesinger\u27s Vision of America and the Multicultural Debate by Jesse M. Vazquez [PDF]

open access: yes, 1993
In April of 1990, Arthur M. Schlesinger, Jr., published an essay in the Wall Street Journal entitled When Ethnic Studies are Un-American. [1] The publication of that article followed, by about eight months, the release of New York State\u27s Department ...
Vazquez, Jesse M.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Understanding 21st century skills needed in response to industry 4.0: Exploring scholarly insights using bibliometric analysis

open access: yesTelematics and Informatics Reports
International policy agendas are increasingly focusing on the 21st century skills needed by future workers in response to Industry 4.0. In this study, we conduct a bibliometric analysis of 2662 articles published by 6579 authors in the last two decades ...
Sumayya Saleem   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Picturing Teacher Agency: Developing Upstanding Heuristics in a Middle Grades Social Studies Methods Course [PDF]

open access: yes, 2019
This paper presents a multi-case study of teacher candidates in a pre-service middle grades social studies methods course. The research aimed to understand how the middle grades teacher candidates viewed their future as upstanders with agency in middle ...
Farley, Jennifer, Gallagher, Jennifer L
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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