Results 51 to 60 of about 76,848,152 (253)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

High-Performing Young Musicians’ Playing-Related Pain. Results of a Large-Scale Study

Frontiers in Psychology, 2020
The present study examines the prevalence, localization, frequency, and intensity of playing-related pain (PRP) in a sample of high-performing young musicians. We also address coping behavior and communication about PRP between young musicians, teachers,
Heiner Gembris, Jonas Menze, Andreas Heye, Claudia Bullerjahn   +3 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Persona, Break Glass, Name Plan, Jam (PBNJ): A New AI Workflow for Planning and Problem Solving

AI
This self-study presents Persona, Break Glass, Name Plan, Jam (PBNJ), a human-centered workflow for using generative AI to support differentiated lesson planning and problem solving.
Laurie Faith, Tiffanie Zaugg, Nicole Stolys, Madeline Szabo, Fatemeh Haghi, Charles Badlis, Simon Lefever Olmedo   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Decoding Subjective Understanding: Using Biometric Signals to Classify Phases of Understanding

AI
The relationship between the cognitive and affective dimensions of understanding has remained unexplored due to the lack of reliable methods for measuring emotions and feelings during learning.
Milan Lazic, Earl Woodruff, Jenny Jun
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Center on Disability Studies eNewsletter, June 2022 [PDF]

, 2022
Featuring Employment First Bill passing, Summer ASD Swim Facts, 'Worry Time' Tips, Parent Resources w/ Sandra Oshiro, Meriah Nichols and Susan Rocco, Dr.
Moriyasu, Annie, Raphael, Raphael, Matheis, Maya, Oshiro, Sandra, Galeaʻi, Jared, Takahashi, Kiriko, Manaseri, Holly, Murphy, Kelle, Stodden, Robert, Park, Hye-Jin, Hooey, Eben, Nichols, Meriah, Leong, Genesis M.K., Kato, Lauren   +13 more
core   +1 more source

The interconnection of STEAM areas in the study of functions

International Journal of Educational Research Open
Current guidelines for mathematics education recommend carrying out activities within interdisciplinary contexts, specifically from an integrative STEAM perspective.
Floriano Viseu, Sara Gonçalves, Paula Mendes Martins   +2 more
doaj   +1 more source