Results 171 to 180 of about 1,547,013 (304)

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Correction: A Novel Two-Step Ultrasound-Guided Technique for Anesthesia and Postsurgery Analgesia in Gluteal Augmentation Surgery. [PDF]

Cureus
Fajardo Perez M, Espinoza Morales K, Rodriguez Sojo JF, Prada Castellnos Y, Galluccio F.   +4 more
europepmc   +1 more source

A Microfluidic Digital Shutter of Liquid–Liquid Interface for Fabrication of Multifaceted Hydrogel Microfiber Structure

Advanced Science, EarlyView.
A programmable passive digital shutter based on multiphase liquid–liquid interface dynamics is introduced for precise fabrication of hydrogel microfibers. By modulating the shutter operation, microfibers with tunable geometry—including linear, helical, tadpole‐like, and spherical forms—are produced.
Dongrui Zhang, Jiangyue Liu, Hao Ye, Yu Shen, Haoran Su, Zhuqing Liang, Kexin Li, Xing Zhang, Shiyi Yang, Yunfei Lu, Zhexi Zhang, Sihang Liu, Yi Huang, Xiao Liu, Yubo Fan   +14 more
wiley   +1 more source

Pourquoi l’atelier compte-t-il plus que jamais ?

Perspective, 2014
Rachel Esner
doaj   +1 more source

Antimicrobial activity and antifungal mechanistic study of 3‑substituted oxindoles against Aspergillus niger. [PDF]

Sci Rep
Ezelarab HAA, El-Bouseary MM, Yahia R, Abd El-Baky RM, Mawhoup MA, Ahmed EF, Sadiq GM, Ali TFS, Abbas SH, Hassan HA, Beshr EAM.   +10 more
europepmc   +1 more source

AMuST: Accessible Music Studio - Feasibility Report [PDF]

, 2013
Bryan-Kinns, Nick, Metatla, Oussama, Stockman, Tony   +2 more
core  

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Quality of life, mental health, and socio-demographic differences across sex work settings: implications for specialized healthcare and support services. [PDF]

Front Public Health
Kalinowski O, Kroehn-Liedtke F, Kaya G, Lotysh A, Mihaylova H, Sipos K, Zerbe LK, Schouler-Ocak M, Rössler W.   +8 more
europepmc   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

DSI Studio: an integrated tractography platform and fiber data hub for accelerating brain research. [PDF]

Nat Methods
Yeh FC.
europepmc   +1 more source