Results 31 to 40 of about 7,018 (199)

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

open access: yesAdvanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu   +8 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao   +8 more
wiley   +1 more source

“If I Die, I Die”: Women Missionary Workers Among Danes, Armenians, and Turks, 1900-1920

open access: yesInternational Journal of Armenian Genocide Studies, 2019
Based on extensive studies of archival material and little-known contemporary published sources, this article will explore how and why Danes – famous in certain circles like Maria Jacobsen, virtually unknown like Hansine Marcher and Jenny Jensen, but ...
Matthias Bjørnlund
doaj  

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

open access: yesAdvanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru   +6 more
wiley   +1 more source

The problems of the students studying abroad in the early periods of the Republic (1923-1940)

open access: yesTurkish Journal of Education, 2016
In this study the problems of the students who were sent to abroad in the early years of the Republic are analysed within the scope of accessible data and documents. In this qualitative study the method is determined as historical research method.
Cengiz Aslan
doaj   +1 more source

Dynamic Reconstruction‐Engineered Heterointerfaces for Acidic Hydrogen Evolution at Ampere‐Level Current Density

open access: yesAdvanced Science, EarlyView.
A dynamic reconstruction strategy was utilized to construct PtCu/Cu3P heterostructures on the surface of self‐supporting Cu3P nanowires. The loose porosity in the restructured layer, together with a dynamic “dissolution‐redeposition” equilibrium during electrocatalysis, enables the electrode to maintain a low, stable overpotential for 240 h at ampere ...
Kaixi Wang   +3 more
wiley   +1 more source

Ultra-Russian, Ultra-Besieged: Kaliningrad Oblast, EU Enlargement and Memory Politics in Russia

open access: yesSprawy Międzynarodowe
Memory politics in Russia has experienced substantial evolution since Vladimir Putin’s comeback to presidential seat in 2012 and the so-called new conservative project.
Miłosz J. Cordes
doaj   +1 more source

Endobody: Genetically Encodable Nanobody‐CPP Chimeras for Degradation of Membrane and Extracellular Proteins

open access: yesAdvanced Science, EarlyView.
We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou   +3 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

open access: yesAdvanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu   +10 more
wiley   +1 more source

From Awareness to Cultural Agency: EFL Colombian Student Teachers’ Travelling Abroad Experiences

open access: yesProfile: Issues in Teachers' Professional Development, 2015
Colombian English as a foreign language student teachers’ opportunities to grow as educators through international sojourns do not usually subsume the traditional study and residence abroad goal.
John Jairo Viafara González   +1 more
doaj   +1 more source

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