Results 131 to 140 of about 350,648 (251)

Food Hygiene Practices Among Preschool Food Handlers in eThekwini, KwaZulu Natal, South Africa: A Cross-Contamination Perspective. [PDF]

Environ Health Insights
Babulall M, Lange S, Van Wyk RH.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A clinician-centric intelligent method towards reliable pancreatic cancer vascular invasion assessment: a retrospective, multi-centre study. [PDF]

Lancet Reg Health West Pac
Guo R, Zhang M, Zhu H, Tang X, Fu W, Li M, Hu H, Xiao X, Wang W, Liu YB, Feng ST, Chen T, Qian X.   +12 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Basic management of life-threatening emergencies in primary healthcare centres: a systematic review protocol on obstacles and facilitators. [PDF]

BMJ Open
Amir-Behghadami M, Gholipour K.
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Health Care Provider Perceptions of Screening for Early-Stage Type 1 Diabetes-A Survey Study. [PDF]

Diabetes Obes Metab
Cherdron C, Achenbach P, Ackermann K, Haupt F, Heublein A, Knopff A, Schill S, Schmidt J, Stock J, Winkler C, Ziegler AG, Hummel S.   +11 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Trends in brachytherapy utilization in Canada from 2011 to 2020. [PDF]

Phys Imaging Radiat Oncol
Dumančić M, Zou Y, Glickman H, Kouraneh SG, Pater P, Alexander A, Aviles JEA, Cherpak A, Marchant K, Menon G, Morton D, Olding T, Paudel M, Rink A, Spadinger I, Enger SA.   +15 more
europepmc   +1 more source