Results 151 to 160 of about 1,425,532 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Preparedness for blackouts in Iberian Peninsula patients using home respiratory therapies. [PDF]

ERJ Open Res
Jiménez-Gómez M, Sayas-Catalán J, Hernando-Sanz A, Ribeiro C, Seabra B, Luján-Torné M.   +5 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

High Suburban Fertility: Evidence from Four Northern European Countries [PDF]

This study examines fertility variation across different residential contexts in four Northern European countries: Denmark, Finland, Norway and Sweden. We move beyond the conventional urban-rural focus of most previous studies of within-nation variations
Gunnar Andersson, Hill Kulu, Paul Boyle
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Current availability and status of paediatric cardiac transplantation and mechanical circulatory support in twenty-eight European countries. [PDF]

Eur J Pediatr
van der Have O, Dunne E, Tran-Lundmark K, Wacker J, Michel-Behnke I, Koubsky K, Krauss A, Van Cleemput J, Stephensen SS, Dalinghaus M, Šijak D, Topalovic M, Lubaua I, Ulger Z, Vida V, Juul K, Balmer C, Mesihovic-Dinarevic S, Fragata J, Maruszewski B, Sarkola T, Ablonczy L, Muntean I, Zahorec M, Chaudhari M, Möller T, Bonnet D, Simmonds J, Reinhardt Z, McMahon CJ.   +29 more
europepmc   +1 more source

Four-centre study of anaesthetic outcomes [PDF]

Canadian Journal of Anaesthesia, 1993
P H, Norman, M D, Daley
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Adrenal tumour diagnostic pathway: findings from a national survey in the United Kingdom. [PDF]

Endocr Connect
Criseno S, Ravi S, Sagu R, Gillett C, Prete A, Ronchi CL.   +5 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source