Results 171 to 180 of about 1,425,532 (305)

Barriers to conducting prospective multicentre studies in paediatric orthopaedics in Europe: Insights from the EPOS Discoid Meniscus (DiMe) project. [PDF]

J Child Orthop
Turati M, Crippa M, Nicolaou N, Tassistro E, Thüsing M, Sinikumpu J, Courvoisier A, Cabral JJ, Duart J, Tschopp B, Tercier S, Lehoczky G, Vandergugten S, Maxim AV, Davies N, Montanari L, Galimberti S, Bigoni M, Accadbled F.   +18 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Healthcare cost trajectories with a multidisciplinary team model: a three-year follow-up from Finnish primary and secondary care. [PDF]

Scand J Prim Health Care
Jokelin E, Piirainen L, Nissen M, Mustonen E, Torkki P.   +4 more
europepmc   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Correction: Children's outdoor play at early learning and child care centres: Examining the impact of environmental play features on children's play behaviour. [PDF]

PLoS One
Ramsden R, Pike I, Thorne S, Brussoni M.
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Access to lymphangioleiomyomatosis care across Europe: an ERN-LUNG survey of clinical practice, and the case for a European registry and trial network. [PDF]

ERJ Open Res
O'Malley D, Humbert-Dorfmüller E, Barberà JA, van Batenburg A, Bendstrup E, Cottin V, Elia D, Froidure A, Grutters J, Harari S, Hernandez-Gonzalez F, Kokosi M, Lund TK, Manali ED, Meszaros G, van Pottelberge G, Radzikowska E, Sellares J, Svenningsson A, Veltkamp M, Wagner T, Hebestreit H, McCarthy C.   +22 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Glucocorticoid-prescribing trends in congenital adrenal hyperplasia, 2017 to 2023. [PDF]

Endocr Connect
Roxas A, Gihawi A, Makarchuk M, Bryce J, Chen M, Ahmed SF, Ali SR, Drake A, Casipe M, Groves L, Idkowiak J, Krone R, Flueck C, Nordenström A, Reisch N, Claahsen-van der Grinten HL, Adriaansen BPH, Birkebaek NH, Hannema S, O Reilly MW, Cussen L, Zaric SP, Neumann U, Baronio F, Vieites A, Alonso GF, Elsedfy H, Mazen I, Thankamony A, Witczak J, Rees DA, Atapattu N, Seneviratne SN, Cools M, El Kaddouri H, Ferri Perez A, Guven A, Poyrazoglu S, Fu A, Janus D, Globa E, Shenoy S, de Bruin C, Korbonits M, Adam S, Wasniewska M, Russo G, Phan-Hug F, Bonfig W, Salerno M, Tomlinson JW, Leka-Emiri S, de Vries L, Yarhere I, Guaranga-Filho G, van Eck J, Bachega TASS, Krone N, De Bono M, Davies JH, Segev-Becker A, Iotova V, Lenherr-Taube N, German A, Giordano R, De Sanctis L, Probst U, Markosyan R, Brewer DS, Costa EC, Webb EA.   +70 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source