Results 161 to 170 of about 1,425,532 (305)

Caring for young minds: general practitioners' self-assessed competence in child and adolescent psychiatry. [PDF]

Scand J Prim Health Care
Söderström L, Knez R, Dalemo S.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mapping transition of care for rare endocrine conditions: findings from a cross-sectional survey by the Endo-ERN ToC Working Group. [PDF]

Endocr Connect
Carlomagno F, Spaziani M, Gaasterland CM, Lajic S, Reisch N, Neumann U, Grasemann C, Kassi E, Ubertini G, Reschke F, Maffei P, Verrijn Stuart A, O'Connell SM, Giavoli C, Fintini D, Charmandari E, Biermasz NR, Iotova V, Claahsen-van der Grinten HL, Stochholm K, Craiu D, Badea AI, Kyrilli A, Le Roux E, Neggers S, Döhnert U, Isidori AM.   +26 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Impact of an early warning system on the outcome of patients with haematological malignancies receiving high-dose chemotherapy with or without haematopoietic cell transplantation: a protocol of the ALHERT cluster randomised trial. [PDF]

BMJ Open
Taillantou-Candau M, Kouatchet A, Darsonval A, Monmousseau F, Darras E, Schmidt A, Riou J, Orvain C.   +7 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Public versus private clinical radiography training in Lagos State, Nigeria: a comparative cross-sectional survey of associations with graduate self-perceived competence and practice readiness. [PDF]

BMJ Open
Udo EO, Emordi OR, Kalu EI, Enebeli UU, Uzochukwu B, Kalu FA, Igwe PC, Kalu JJ, Kalu BO, Cherima YJ, Nwokenna US, Hassan RK, Amadi AN.   +12 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A comprehensive dated phylogeny of China's vascular plants reveals a hidden global biodiversity hotspot. [PDF]

Nat Ecol Evol
Feng YL, Hu HH, Liu B, Peng DX, Yang YC, Barrett RL, Antonelli A, Chen ZD, Lu LM.   +8 more
europepmc   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source