Results 231 to 240 of about 45,221,204 (354)

Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres.

Gut, 1988
S. Gyde, P. Prior, R. Allan, A. Stevens, D. Jewell, S. Truelove, R. Löfberg, O. Broström, G. Hellers   +8 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cost-Effectiveness Analysis of an Intracranial Stereotactic Radiotherapy Service for Brain Metastasis in a North Queensland Regional Cancer Centre. [PDF]

Cancers (Basel)
Zhang Q, Gao L, Das N, Squire T, Stoker D, Shakya R, Patel D, Joshi A, Xing T.   +8 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Strengthening Public Policy to Address the Financial Burden of Breast Cancer Care in Nigeria: A Critical Imperative. [PDF]

Cancer Control
Ajala DE, Ogunmodede EO, Ishola RO.
europepmc   +1 more source

Clinical outcome in relation to care in centres specialising in cystic fibrosis: cross sectional study

, 1998
R. Mahadeva, K. Webb, R. C. Westerbeek, N. R. Carroll, M. Dodd, D. Bilton, D. Lomas   +6 more
semanticscholar   +1 more source

European multicentre study to define disease activity criteria for systemic sclerosis.* I. Clinical and epidemiological features of 290 patients from 19 centres

Annals of the Rheumatic Diseases, 2001
A. D. Rossa, G. Valentini, S. Bombardieri, W. Bencivelli, A. Silman, S. d'Angelo, M. Cerinic, J. J. Belch, C. Black, R. Bečvář, P. Bruhlman, Franco Cozzi, L. Czirják, A. Drosos, B. Dziankowska, C. Ferri, A. Gabrielli, R. Giacomelli, G. Hayem, Murat Inanc, N. McHugh, H. Nielsen, R. Scorza, E. Tirri, F. V. D. Hoogen, P. Vlachoyiannopoulos   +25 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Implementation of basic training in neonatal resuscitation in the outskirts of Conakry, Guinea: evaluation of neonatal mortality by 'before and after intervention' design. [PDF]

BMJ Glob Health
Diallo M, Keita BM, Conté N, Diallo IS, Lomme C, Diallo MM, Condé B, Kondé MK, Roth-Kleiner M.   +8 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source