Results 241 to 250 of about 7,721,321 (318)

SEMASEARCH Study Design: Real-World Evaluation of Semaglutide 2.4 mg in Adults With Severe Obesity Underrepresented in Clinical Trials. [PDF]

Diabetes Obes Metab
Bel Lassen P, Jacobi D, Brindisi MC, Bonnet JB, Subtil F, Bin S, Abad F, Poitou C, Segrestin B, Ledoux S, Gaborit B, Aron-Wisnewsky J, Carette C, Zerguine M, Gatta-Cherifi B, Quilliot D, Montastier E, Avignon A, Mosbah H, Czernichow S, Disse E.   +20 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Fecal AAV8 shedding and co-housing reduces EAE disease severity: implications for preclinical study design. [PDF]

Front Med (Lausanne)
Gaddie CD, Keeler GD.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Response to the Letter to the Editor, "Can case control study design investigate the association of BPG levels, inflammatory cytokines with valvular dysfunction". [PDF]

Indian Heart J
Kumar S.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Study Design and Conceptual Framework of an Observational Study of Food Insecurity and Life's Essential 8 in College Students: The FRESH Study. [PDF]

J Am Heart Assoc
Martinez SM, Chodur GM, Singh S, Grandner MA, McCulloch CE, Bullock HE.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Seasonality of anti-Leishmania infantum titers in dogs: a crucial factor for designing effective clinical trials

Frontiers in Veterinary Science
Maria Alfonsa Cavalera, Oana Gusatoaia, Andrea Zatelli   +2 more
doaj   +1 more source

The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort. [PDF]

J Allergy Clin Immunol Glob
O'Shea KM, Brooks E, Polmear-Swendris N, Slack IF, Smith JA, Gordon A, Aquino DM, Gern JE, Khurana Hershey GK, Johnson CC, Wilkowski J, Hines J, Lukacs NW, Schuler CF, Baker JR.   +14 more
europepmc   +1 more source