Results 251 to 260 of about 7,721,321 (318)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Epilepsy journey 2.0 study design and methods: A randomized trial of an executive functioning intervention for adolescents with epilepsy. [PDF]

Contemp Clin Trials Commun
Combs AB, Wagner JL, Huszti H, Wade SL, Schmidt M, Buschhaus S, Scherra J, Wetter-Wren SE, Ogundairo D, Coffey C, Ecklund D, Bayman E, Bhatia S, Glauser T, Hardy KK, Modi AC.   +15 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Association between women's empowerment dimensions and use of skilled birth attendance in southwest Ethiopia: a community-based cross-sectional study design. [PDF]

BMC Pregnancy Childbirth
Benti NB, Tebeje B, Mamo F, Lemma M, Kajela L, Ganeti DD.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Commentary: Eighteen cases of renal aneurysms: clinical retrospective analysis and experience of endovascular interventional treatment

Frontiers in Surgery
Som P. Singh, Ursula Qureshi, Farah Qureshi, Fawad Qureshi   +3 more
doaj   +1 more source

The Electronic Medical Records and Genomics study: Design and analytic framework for assessing the impact of genome-informed risk assessments. [PDF]

Am J Hum Genet
Limdi N, Beasley TM, Cortopassi J, Davis B, Bangash H, Chen J, Chisholm RL, Chung WK, Cimino JJ, Connolly J, Crosslin DR, Davis KW, DiVietro A, Esplin ED, Freimuth B, Gordon A, Hakonarson H, Hamed M, He M, Hoell C, Holm I, Hripscak G, Irvin MR, Jarvik GP, Karavite D, Karlson EW, Kenny EE, Khan A, Kiryluk K, Knerr S, Korf B, Kottyan L, Kullo I, Larkin K, Lennon N, Linder JE, Manolio T, Martin LJ, McNally EM, Morse J, Murphy S, Namjou B, Odgis JA, Orlando L, Pacheco J, Peterson JF, Pineda-Alvarez DE, Prows C, Puckelwartz M, Purcell J, Rasmussen-Torvik L, Rehm H, Roden DM, Rosenthal EA, Rowley R, Sabatello M, Schaid D, Sharp R, Smith JL, Smoller JW, Soper ER, Sterling R, Suckiel SA, Terek S, Thayer J, Ting YL, Tiwari H, Velez-Edwards D, Wagholikar KB, Walunas T, Wei WQ, Weng C, Wiesner G, Abul-Husn NS, Veenstra DL.   +74 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Adipose tissue-derived mesenchymal stromal cell therapy in nonischemic heart failure with reduced ejection fraction - ARIISE study design. [PDF]

Future Cardiol
Chaaban N, Kastrup J, Rossing K, Schou M, Hove J, Buch P, Ekblond A, Johansen EM, Nørgaard MJ, Højgaard LD, Qayyum AA.   +10 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source