Results 161 to 170 of about 4,398,549 (286)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Impact of a Short Study Skills Course on Depressive Symptoms Among Medical Students. [PDF]

Cureus
AlFaris E, Ahmed AM, Irfan F, Alosaimi FD, Ponnamperuma G, Al-Mazroua H, AlSaif H, Ahamed SS, Alwazzan L, Akresh M, Al-Hasani S, Aldoghmani RA, Abdulghani MY, Jazzar F, Alzoghaibi A.   +14 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Detecting change processes during an ACT-based course for enhancing university students' well-being and study skills. [PDF]

Front Psychol
Katajavuori N, Rönkkönen S, Postareff L, Rytkönen A, Asikainen H.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Assessing and Improving Study Skills Support in Medical Education Through a Student-Staff Partnership: Mixed Methods Approach. [PDF]

JMIR Med Educ
Tay N, Deere A, Ilangovan D, Phillips CFE, Kelley E.   +4 more
europepmc   +1 more source

The relationship between study skills and depressive symptoms among medical residents. [PDF]

BMC Med Educ, 2019
AlFaris E, AlMughthim M, Irfan F, Al Maflehi N, Ponnamperuma G, AlFaris HE, Ahmed AMA, van der Vleuten C.   +7 more
europepmc   +1 more source

“What do I need?” – evaluating learner perceptions of digital literacy skills development to inform enhancements to learning design

, 2012
The ability to demonstrate digital literacy skills, defined by the European Commission as the confident and critical use of ICT for work, leisure, learning and communication, is a key requirement for graduates, demanded both by the UK Quality Assurance ...
Baker, Kirsty, Hall, Marion, Nix, Ingrid
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Promoting mental health among at-risk adolescents in Malaysia (MyHeRo): study protocol for a cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of a school-based intervention compared with study skills condition for adolescents identified as at risk for anxiety and depression. [PDF]

Trials
Essau CA, Zakaria S, Ting CH, Lee JAC, de la Torre-Luque A, Ng ALO, Majid HA, Dodd H, Nik Farid ND, Muhammad NA, Wahab S.   +10 more
europepmc   +1 more source