Results 231 to 240 of about 1,449,701 (289)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cluster-randomized trial of Homework, Organization, and Planning Skills program compared to treatment as usual/waitlist for youth ages 11-14: Study protocol for conceptual replication. [PDF]

PLoS One
Nissley-Tsiopinis J, Fleming PF, Chan W, Langberg JM, Cacia J, Vigil T, Chamberlin B, Di Bartolo CA, Tremont KL, Walz EH, Jawad AF, Mautone JA, Power TJ.   +12 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Enhancing comprehensive clinical competence in nursing students through intensive diabetes management training: A mixed-methods study. [PDF]

J Educ Health Promot
Yazdani F.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A comparative analysis of traditional and technology-supported stepped teaching for clock and fraction reading skills in students with dyscalculia. [PDF]

Front Psychol
Kaya N, Akçamete G, Sakallı Demirok M.
europepmc   +1 more source

Cooking-Related Skills and Food Sustainability-Related Practices: A Systematic Review. [PDF]

Foods
Nucci D, Pennisi F, Pinto A, Gianfredi V, Signorelli C.   +4 more
europepmc   +1 more source

The Effect of Sex and Gender-Role on Social Attention: Investigating the Association With Social Skills and Academic Preferences. [PDF]

Int J Psychol
Chacón-Candia JA, Lupiáñez J, Casagrande M, Marotta A.   +3 more
europepmc   +1 more source

Bidirectional Relations Between Spatial and Mathematics Skills in Elementary School Children: The Role of Domain-Specific Anxieties. [PDF]

J Intell
Geer EA, Barroso C, Ganley CM.
europepmc   +1 more source

Exploratory Graph Analysis Failed to Reproduce the Hypothesized Functional Zoning Framework in the OECD Survey on Social and Emotional Skills. [PDF]

Psych J
Wang L, Ning B.
europepmc   +1 more source