Results 51 to 60 of about 1,230,030 (294)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

L’homme dans le style, et réciproquement

open access: yes, 2015
On peut rapporter les nombreuses définitions du style à deux orientations majeures : l’une considère qu’il y a style dès qu’il y a caractéristique, l’autre identifie le style au produit d’un certain artisanat qui cherche à perfectionner le langage et à ...

core   +1 more source

Editorial

open access: yesLifespans and Styles, 2017
It is my pleasure to present the first issue of the third volume of Lifespans & Styles: Undergraduate Working Papers on Intraspeaker Variation . This issue includes five papers on topics about within-speaker variation that are largely under-researched in
Lauren Hall-Lew
doaj   +3 more sources

Black Country English in the Spotlight: A Stylistic Analysis of Variable Contrast between Phonemes in an Urban Regiolect of British English

open access: yesLifespans and Styles, 2016
When examining the COT /CAUGHT merger in central Pennsylvania, Labov (1994) uncovered a stylistic phenomenon, known as the “ Bill Peters Effect” , whereby speakers heavily differentiate between /ɑ/ and /ɔː/  in spontaneous speech, but converge the two ...
Joel Merry
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Shifting register windows. [PDF]

open access: yes, 1993
Shifting register windows is a new register windowing method that attempts to overcome some of the difficulties of traditional fixed- and variable-sized schemes.
Shaw, Paul, Russell, Gordon
core   +1 more source

Changes in Code-Switching Patterns among Hindi-English Bilinguals in Northern India

open access: yesLifespans and Styles, 2017
This study investigates changes in code-switching (CS) patterns among Hindi-English bilinguals in Northern India. There is a dearth of studies of naturalistic Hindi-English CS, which this study attempts to address.
Anita Klingler
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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