Results 51 to 60 of about 30,066 (258)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Una propuesta para el próximo milenio
Cuadernos LIRICO, 2013 Inspired by the Six proposals de Ítalo Calvino this essay displays an additional one. On that purpose the author analyses the discursive modalities used by Rodolfo Walsh when he intends to communicate an event that seems impossible to be told.
Ricardo Piglia
doaj +1 more source
Light Logics and the Call-by-Value Lambda Calculus [PDF]
Logical Methods in Computer Science, 2008 The so-called light logics have been introduced as logical systems enjoying quite remarkable normalization properties. Designing a type assignment system for pure lambda calculus from these logics, however, is problematic.
Paolo Coppola +2 more
doaj +1 more source
Embodying shifting political styles
Asia-Pacific Language VariationAbstract This study examines multimodal linguistic variation in the political discourse of Taiwanese legislator Pin-Yu Lai (PYL), focusing on her stylistic shifts during parliamentary interpellations. Employing both acoustic and gestural analysis, we explore her transition from a polite junior ...
Tsung-Lun Alan Wan, NienEn Bonnie Liu
openaire +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Frontiers in Psychology, 2018 One centennial discussion in linguistics concerns whether languages, or linguistic systems, are, essentially, homogeneous or rather show “structured heterogeneity.” In this contribution, the question is addressed whether and how sociolinguistically ...
Anne-Sophie Ghyselen +1 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
International Journal For Multidisciplinary ResearchParenting style refers to the combination of attitudes, practices, and emotional climate that parents create when interacting with their child. This paper aims to compare the parenting style of parents in the present generation with the previous generation.
openaire +1 more source