Results 61 to 70 of about 516,529 (294)

The 'public inquisitor' as media celebrity [PDF]

open access: yes, 2010
This article looks at the development and utility of celebrity among high-profile political interviewers. Offering the revised description 'public inquisitor', the article presents an overview of the rise of the political interviewer as a celebrity form ...
Higgins, Michael
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Embedding social innovation and social impact across the disciplines: identifying "Changemaker" attributes [PDF]

open access: yes, 2015
Purpose—This paper proposes an attributes framework for embedding “Changemaker”—a university initiative for promoting social innovation and social impact—across the disciplines at the University of Northampton.
Alden Rivers, Bethany   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Style: Notes on the Transformation of a Concept

open access: yesArchitectural Histories, 2019
Style has been a key concept in architectural discourse since the 18th century, yet its meaning is far from unequivocal. This essay traces the shifting meanings attributed to style in German architectural thinking from the mid-18th to the early 19th ...
Mari Hvattum
doaj   +1 more source

Candles of Dickens in the Darkness of Victorian Era: Common Symbols in Christmas Books [PDF]

open access: yes, 2019
The aim of this study is to stylistically analyze the common symbols in Charles Dickens’s Christmas Books, which revived the Christmas spirit in the dark Victorian era. Experiencing the vast impacts of Industrial Revolution, people in Dickens’s time were
Kaya, Senem Üstün
core  

Key research themes on travel behavior, lifestyle, and sustainable urban mobility [PDF]

open access: yes, 2016
The concept of lifestyle adds a behavioral component to travel models that used to be dominated by engineering and econometric traditions. This article presents an overview of how lifestyle is defined and measured in transport studies, and how travel ...
Goodwin, Phil   +2 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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