Results 81 to 90 of about 516,529 (294)

The Hair Dilemma: Conform to Mainstream Expectations or Emphasize Racial Identity [PDF]

, 2007
Throughout American history, skin color, eye color, and hair texture have had the power to shape the quality of Black people\u27s lives, and that trend continues today for Black women in the ...
Dumas, Tracy L., Rosette, Ashleigh Shelby   +1 more
core   +1 more source

The challenges of change:Exploring the dynamics of police reform in Scotland [PDF]

, 2019
Despite a long tradition of pessimism regarding the scope for meaningful change in police practices, recent structural reforms to police organizations in several European countries suggest that significant change in policing is possible.
Donnelly D, Fyfe NR, Fyfe NR, Fyfe NR, Fyfe NR, Fyfe NR, Fyfe NR, Her Majesty’s Inspectorate of Constabulary in Scotland (HMICS), Loader I, Marshall C, Murray K, Nicholas R. Fyfe, Police Scotland, Savage S, Scottish Government, Scottish Government, Scottish Police Authority, Scottish Police Authority, Scottish Police Authority, SIPR, Scotcen and What Works Scotland, SIPR, Scotcen and What Works Scotland, SIPR, What Works Scotland and Scotcen, SIPR, What Works Scotland and Scotcen, SIPR, What Works Scotland and Scotcen, Sparrow M, Terpstra J   +25 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The Interplay between attention, experience and skills in online language teaching [PDF]

, 2017
The demand for online teaching is growing as is the recognition that online teachers require highly sophisticated skills to manage classrooms and create an environment conducive to learning.
Lloyd, Mair E., Shi, Lijing, Stickler, Ursula   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pension reform in Croatia [PDF]

Croatia's transition toward independence, and the market economy in the 1990s, exacerbated problems in the pay-as-you-go (PAYG) system, and ultimately led to its financial collapse. Although a comprehensive three-pillar reform was initiated in late 1995,
Anusic, Zoran, Madzarevic-Sujster, Sanja, O"Keefe, Philip   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Models of digitisation of organisational space in sport

Journal of Education, Health and Sport, 2019
This research presents the organisational model of digitisation of sport institutions as the element of development shifting towards digital models of sport business.
Wojciech Cieśliński, Paweł Piepiora, Kazimierz Witkowski   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source