Results 81 to 90 of about 30,604 (290)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Applications of global equity style indices in active and passive portfolio management [PDF]

, 2010
Includes abstract.Includes bibliographical references.The success of the Fama and French 3-factor model in explaining empirical anomalies of the Capital Asset Pricing Model (CAPM) suggests that style investing which places portfolios out-of-sync with the
Hsieh, Heng-Hsing
core  

Models of digitisation of organisational space in sport

Journal of Education, Health and Sport, 2019
This research presents the organisational model of digitisation of sport institutions as the element of development shifting towards digital models of sport business.
Wojciech Cieśliński, Paweł Piepiora, Kazimierz Witkowski   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Barack Obama and the [blæk kəˈmjuːnətɛ:] - A study of style-shifting [PDF]

, 2013
This project presents an exemplary study of style shifting. The basis of the project is the hypothesis that Barack Obama strategically employs a style of speech indexical of a distinct African American identity when speaking in front of a black audience ...
Kristensen, Kasper Ravn, Detert, Ann Christin, Sofie, Ditte, Rasmussen, Lundkjær   +3 more
core  

Embodying shifting political styles

Asia-Pacific Language Variation
Abstract This study examines multimodal linguistic variation in the political discourse of Taiwanese legislator Pin-Yu Lai (PYL), focusing on her stylistic shifts during parliamentary interpellations. Employing both acoustic and gestural analysis, we explore her transition from a polite junior ...
Tsung-Lun Alan Wan, NienEn Bonnie Liu
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Levels of style-shifting : exemplified in the interaction strategies of a moderator in a listener participation programme [PDF]

, 2010
This paper investigates speech styles and style-shifting in the speech of the moderator of a German radio participation programme. Style-shifting is shown to affect several distinct linguistic levels: phonetic, morphophonemic, syntactic, and lexical. The
Selting, Margret
core