Results 101 to 110 of about 30,604 (290)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
"Mee siam mai hum" : style-shifting and code-mixing in election rallies [PDF]
, 2020 This paper discusses the linguistic practices of Singaporean political leaders, Lee Hsien Loong and Pritam Singh. Specifically, it aims to look at their style-shifting and code-mixing strategies when they are performing election rally speeches. This will
Teoh, Yong Qin
core
Shifting Leadership Styles in The Church
, 2018 Everyone accepts the fact that ‘effective leadership’ is a must in any organization if it must be successful and survive; and everyone accepts that the effectiveness of an organization depends on the results achieved through the practice of leadership. Everyone also accepts the fact that the criterion of leadership success is the effective performance ...
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Style shifting in Spanish and English across three English proficiency levels at the University of Puerto Rico at Mayagüez [PDF]
, 2006 This thesis examines the phonetic-phonological resources for style-shifting in English and Spanish of twelve students at the University of Puerto Rico, Mayagüez. It used social networks to locate students at three English proficiency levels. To collect
Hermina Hermina, Jannette
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Style shifting, code switching [PDF]
, 2007 Changing English examines the history of English from its origins in the fifth century to the present day. It focuses on the radical changes that have taken place in the structure of English over a millennium and a half, detailing the influences of ...
Swann, J., Sinka, I.
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source