Results 61 to 70 of about 153,105 (290)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Biomarkers of Selenium Toxicity after Sub-Acute Exposure in Mice [PDF]
Journal of Molecular Biomarkers & Diagnosis, 2013 Selenium (Se) is a trace element, essential for human health but it can be toxic at moderately higher intake levels. In this study biomarkers of Se toxicity after sub-acute intra-peritoneal exposure to Se (62.5 µg Se/kg bw/ day; 14 days) were investigated in mice. Such exposure corresponds to high human Se-intake levels. Focus was put on the biomarkers
Jansen, E +6 more
openaire +3 more sources
Nanomaterials, 2021 Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread applications. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent
Adrián García-Salvador +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Toxicological profile of the aqueous-fermented extract of Musa paradisiaca in rats [PDF]
Avicenna Journal of Phytomedicine, 2018 Objective: This study was conducted to assess the toxicity profile of the aqueous-fermented extract of Musa paradisiaca in rats. Materials and Methods: In acute toxicity test, the rats of different groups were orally administered with a single dose of ...
Eziuche Ugbogu +5 more
doaj +1 more source
Toxicology Reports, 2021 The present study was carried out to assess the oral safety, proinflammatory and stress response effect of Terminalia catappa aqueous leaf extract (TCA) in male Wistar rats.
Franklyn Nonso Iheagwam +5 more
doaj +1 more source
Electrochemical peroxidation of contaminated water and assessment of the toxicity using existing and novel bioassays [PDF]
, 2011 The treatment of wastewater and monitoring of its toxicity is essential before discharging it to the environment. This study focuses on assessing the toxicity of wastewater following treatment using the electrochemical peroxidation process (ECP). Three
Kokkali, Varvara
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Acute and sub-acute toxicity studies on an antidiabetic polyherbal formulation in mice [PDF]
, 2022 Purpose: To investigate the acute and sub-acute toxicity of an Indonesian polyherbal formulation in experimental mice. Methods: Young and healthy Swiss albino mice of both sexes (5 – 6 weeks old), weighing 24 – 25 g were used in this study.
Dewi, Qonita S. +2 more
core +2 more sources
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Modeling of the Acute Toxicity of Benzene Derivatives by Complementary QSAR Methods [PDF]
, 2013 A data set containing acute toxicity values (96-h LC50) of 69 substituted benzenes for fathead minnow (Pimephales promelas) was investigated with two Quantitative Structure- Activity Relationship (QSAR) models, either using or not using molecular ...
Duce, Celia +3 more
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