Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
The Social Construction of the Audit Expectation Gap: The Market of Excuses [PDF]
Nous examinons dans cet article l'“audit expectation gap” en nous appuyant sur l'étude de l'évolution des objectifs de l'audit dans le contexte français.
Imen Jedidi, Chrystelle Richard
core
Complete convergence for weighted sums of m-widely acceptable random variables under sub-linear expectations [PDF]
Mathematics subject classification (2020): 60F15.In this paper, under the assumption of the existence of Choquet integrals, the complete convergence properties for weighted sums of m-widely acceptable random variables in sub-linear expectation space are ...
Hu, K, Yu, K, Hu, X, Pan, S
core +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Linear maps preserving permutation and stochastic matrices
, 2002 Let T be the set of n×n (sub)permutation matrices, doubly (sub)stochastic matrices, or the set of m×n column or row (sub)stochastic matrices. We characterize those linear maps T on the linear span of T that satisfy T(T)=T .
Nam-Kiu Tsing +6 more
core +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
The self-concordant perceptron is efficient on a sub-family feasibility instances [PDF]
Strict linear feasibility or linear separation is usually tackled using efficient approximation/stochastic algorithms (that may even run in sub-linear times in expectation).
Chan-Hon-Tong, Adrien
core
Computing second-order-accurate solutions for rational expectation models using linear solution methods [PDF]
, 2005 This paper shows how to compute a second-order accurate solution of a non-linear rational expectation model using algorithms developed for the solution of linear rational expectation models.
Sutherland, Alan, Lombardo, Giovanni
core