Results 21 to 30 of about 16,532,093 (224)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Influence of Terrain Parameters on Tire Forces and Moments Under Multi-Pass Loading

Applied Sciences
The dynamic response of soft terrain under repeated vehicle passes significantly influences off-road vehicle mobility and performance. The primary innovation of this research is the integration of loading–unloading hysteresis, multi-pass terrain-state ...
Sadegh Yarmohammadisatri, Corina Sandu
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

At-Rest Earth Pressure Coefficient K₀: Formulations, Physical Assumptions, and Engineering Implications

Applied Sciences
The coefficient of earth pressure at rest, K0, is central to defining initial stress states in soils, yet its estimation remains uncertain because formulations differ in calibration basis, governing variables, and physical meaning.
Edgar Giovanny Diaz-Segura, Jackelline González-Blandón   +1 more
doaj   +1 more source

Setting up the physical principles of resilience in a model of the Earth System [PDF]

Earth System Dynamics
Resilience is a property of social, ecological, social-ecological and biophysical systems. It describes the capacity of a system to cope with, adapt to and innovate in response to a changing surrounding.
O. Bertolami, O. Bertolami, M. Nyström
doaj   +1 more source

Experimental characterization of friction coefficients at the tool-chip-workpiece interface in cutting: Evaluation of lubrication efficiency of mineral oil [PDF]

, 2010
Collaboration avec le LTDS/ENISEThe characterization of friction coefficients at the tool-chip-workpiece interface remains an issue. This paper presents a new experimental set-up able to simulate similar tribological phenomena as the ones occurring at ...
RECH, Joël, FROMENTIN, Guillaume, DUMONT, Florian, MONDELIN, Alexandre, CLAUDIN, Christophe   +4 more
core  

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

Identification and model-based compensation of Striebeck friction [PDF]

, 2006
The paper deals with the measurement, identification and compensation of low velocity friction in positioning systems. The introduced algorithms are based on a linearized friction model, which can easily be introduced in tracking control algorithms ...
Lantos, Béla, Márton, Lőrinc
core   +2 more sources

Break-Out Resistance of Offshore Pipelines Buried in Inclined Sandy Seabed

Journal of Marine Science and Engineering
Submarine pipelines are highly susceptible to lateral buckling failure under service conditions of high temperature and pressure. While existing bearing capacity evaluation methods mainly focus on flat seabeds, research on the ultimate bearing capacity ...
Jingshan Zhu, Siyang Su, Fuquan Chen
doaj   +1 more source