Results 71 to 80 of about 1,315,337 (287)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Videojuegos y subalternidad, una introducción

open access: yesCaracteres: Estudios Culturales y Críticos de la Esfera Digital, 2018
The subaltern concept developed by Gramsci implies a differential and subordinate integration within the tempo of capital, defining the state of subalternity, one of the fundamental characteristics of the dominated classes, as the subjective condition of
Ruth García Martín
doaj  

A Pedagogy as Education to Active Thinking

open access: yesRevista Portuguesa de Pedagogia, 2020
In our study, we analyse some reflections contained in the education thought of John Dewey, Paulo Freire and Peter McLaren. The three thinkers, with mutually different methods, have, in our opinion, as common point the intention to show that no education
Gianluigi Segalerba   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

When Earth Matters: Bessie Head’s When Rain Clouds Gather

open access: yesOpen Cultural Studies, 2019
This essay discusses Bessie Head’s When Rain Clouds Gather from an ecocritical perspective, asking how her late 1960s’ novel already anticipated some of the politics of early twenty-first-century environmental thinking in the postcolonial sphere.
Bayer Gerd
doaj   +1 more source

Ronald Inglehart och populismens uppgång, en kommentar

open access: yes, 2020
En kommentar till Ronald F. Inglehart och Pippa Norris, "Trump, Brexit och populismens uppsving", publicerad i samma nummer (Subaltern 3-4, 2020)
Falk, Hjalmar,
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

POLÍTICAS PÚBLICAS, ESTADO E EDUCAÇÃO: notas a partir dos escritos de Gramsci

open access: yesMovimento, 2017
Tomando como referência os escritos de Antonio Gramsci o objetivo desse artigo é tecer algumas considerações sobre os limites e possibilidades das políticas públicas no contexto das democracias modernas, articulando com os conceitos de Estado e educação.
Anita Helena Schlesener
doaj   +1 more source

Subaltern Literature The seed of Subaltern has grown and bloom to the present level [PDF]

open access: yes, 2018
The paper focuses on the origin and development of subaltern theory. The wordsubaltern was unknown to the writers of history or application in the field of literature. Theword ”subaltern” is drawn or originated from Latin means below all others Sub means‘
J, PONSELVI.
core  

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