Results 41 to 50 of about 61,577 (279)

Randomized, open-label, phase 1/2a study to determine the maximum tolerated dose of intraventricular sustained release nimodipine for subarachnoid hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage]) [PDF]

, 2016
BACKGROUND AND PURPOSE—: We conducted a randomized, open-label, phase 1/2a, dose-escalation study of intraventricular sustained-release nimodipine (EG-1962) to determine safety, tolerability, pharmacokinetics, and clinical effects in aneurysmal ...
Aldrich, Francois, Diringer, Michael N, Etminan, Nima, Faleck, Herbert J, Hanggi, Daniel, Hoh, Brian L, Macdonald, R. Loch, Mayer, Stephen A, Mocco, J, Newton Investigators,, Steiger, Hans Jakob   +10 more
core   +3 more sources

Prophylactic management of cerebral vasospasm with clazosentan in real clinical practice: a single-center retrospective cohort study

Frontiers in Neurology
IntroductionClazosentan, a selective endothelin receptor subtype A antagonist, reduces vasospasm-related morbidity and all-cause mortality following aneurysmal subarachnoid hemorrhage (SAH) in the Japanese population, as demonstrated by a recent ...
Hiroyuki Sakata, Hiroyuki Sakata, Atsushi Kanoke, Hiroki Uchida, Shinya Haryu, Shunsuke Omodaka, Naoto Kimura, Masahiro Yoshida, Kuniyasu Niizuma, Kuniyasu Niizuma, Kuniyasu Niizuma, Kuniyasu Niizuma, Teiji Tominaga, Teiji Tominaga, Hidenori Endo, Hidenori Endo   +15 more
doaj   +1 more source

Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage

Neural Regeneration Research, 2019
Aneurysmal subarachnoid hemorrhage remains serious hemorrhagic stroke with high morbidities and mortalities. Aneurysm rupture causes arterial bleeding-induced mechanical brain tissue injuries and elevated intracranial pressure, followed by global ...
Hideki Kanamaru, Hidenori Suzuki
doaj   +1 more source

Hyperacute pathophysiology of traumatic and vascular brain injury captured by ultrasound, photoacoustic, and magnetic resonance imaging [PDF]

arXiv, 2022
Cerebrovascular dynamics and pathomechanisms that evolve in the minutes and hours following traumatic vascular injury in the brain remain largely unknown. We investigated the pathophysiology evolution within the first three hours after closed-head traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH), two common traumatic vascular injuries, in
arxiv  

The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

Neural Regeneration Research
Subarachnoid hemorrhage leads to a series of pathological changes, including vascular spasm, cellular apoptosis, blood–brain barrier damage, cerebral edema, and white matter injury. Microglia, which are the key immune cells in the central nervous system,
Wenjing Ning, Shi Lv, Qian Wang, Yuzhen Xu   +3 more
doaj   +1 more source

A Case of Sudden Death: Subarachnoid Hemorrhage, Pheochromocytoma, Berry Aneurysm

Case Reports in Pathology, 2019
Subarachnoid hemorrhage is a medical emergency. Berry aneurysm rupture is the second most common cause following trauma. Diagnosis is often challenging. Neurogenic heart syndrome often complicates subarachnoid hemorrhage.
Ana B. Arevalo, Jacxelyn Moran, Stephen Zink, Binny Khandakar   +3 more
doaj   +1 more source

Comparing Conventional and Deep Feature Models for Classifying Fundus Photography of Hemorrhages [PDF]

, 2022
Diabetic retinopathy is an eye-related pathology creating abnormalities and causing visual impairment, proper treatment of which requires identifying irregularities. This research uses a hemorrhage detection method and compares classification of conventional and deep features.
arxiv   +1 more source

Pseudo-subarachnoid hemorrhage and gadolinium encephalopathy following lumbar epidural steroid injection

Radiology Case Reports, 2020
Patients with imaging findings concerning for subarachnoid hemorrhage, however, with no evidence of hemorrhage following autopsy or cerebrospinal fluid testing are diagnosed with having pseudo-subarachnoid hemorrhage.
Andrew Platt, MD, Faten El Ammar, MD, John Collins, MD, PHD, Edwin Ramos, MD, Fernando D. Goldenberg, MD   +4 more
doaj  

A mathematical model of the metabolic and perfusion effects on cortical spreading depression [PDF]

PLoS ONE 8(8) (2013), 2012
Cortical spreading depression (CSD) is a slow-moving ionic and metabolic disturbance that propagates in cortical brain tissue. In addition to massive cellular depolarization, CSD also involves significant changes in perfusion and metabolism -- aspects of CSD that had not been modeled and are important to traumatic brain injury, subarachnoid hemorrhage,
arxiv   +1 more source

Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage

European Journal of Neurology, Volume 30, Issue 1, Page 116-124, January 2023., 2023
Abstract Background and purpose Nuclear factor erythroid 2‐related factor 2 (NRF2; encoded by the NFE2L2 gene) has been implicated in outcome following aneurysmal subarachnoid haemorrhage (aSAH) through its activity as a regulator of inflammation, oxidative injury and blood breakdown product clearance.
Ben Gaastra, Poppy Duncan, Mark K. Bakker, Isabel C. Hostettler, Varinder S. Alg, Henry Houlden, Ynte M. Ruigrok, Ian Galea, Will Tapper, David Werring, Diederik Bulters   +10 more
wiley   +1 more source