Results 41 to 50 of about 81,649 (239)

Neuroprotection mediated by the Wnt/Frizzled signaling pathway in early brain injury induced by subarachnoid hemorrhage

Neural Regeneration Research, 2019
The Wnt/Frizzled signaling pathway participates in many inflammation-linked diseases. However, the inflammatory response mediated by the Wnt/Frizzled signaling pathway in experimental subarachnoid hemorrhage has not been thoroughly investigated ...
Yang Wang, De-Jun Bao, Bin Xu, Chuan-Dong Cheng, Yong-Fei Dong, Xiang-pin Wei, Chao-Shi Niu   +6 more
doaj   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Persistent primitive hypoglossal artery presenting with perimesencephalic nonaneurysmal subarachnoid hemorrhage: A case report and review of literature

Interdisciplinary Neurosurgery, 2020
Background: Persistent primitive hypoglossal artery (PPHA) is a rare remnant of the congenital carotid-basilar artery anastomosis, sometimes associated with subarachnoid hemorrhage (SAH), and aneurysms are the more common cause.
Hui Shen, Qing Mei, Junyan Shen, Fuzheng Zhang   +3 more
doaj   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Microendovascular Neural Recording from Cortical and Deep Vessels with High Precision and Minimal Invasiveness

Advanced Intelligent Systems, EarlyView.
Intravascular electroencephalography (ivEEG) using micro‐intravascular electrodes was developed. Cortical‐vein ivEEG showed a higher signal‐to‐noise ratio and finer spatial resolution of somatosensory evoked potentials (SEPs) than superior sagittal sinus ivEEG, and deep‐vein ivEEG captured clear visual evoked potentials.
Takamitsu Iwata, Hajime Nakamura, Takafumi Uemura, Teppei Araki, Takaki Matsumura, Takaaki Abe, Toshikazu Nezu, Masatoshi Takagaki, Tomohiko Ozaki, Shinpei Miura, Ryohei Fukuma, Sam E. John, David B. Grayden, Haruhiko Kishima, Tsuyoshi Sekitani, Takufumi Yanagisawa   +15 more
wiley   +1 more source

Left Bundle Branch Block Secondary to Subarachnoid Hemorrhage

Eurasian Journal of Emergency Medicine, 2018
Many electrocardiogram changes associated with subarachnoid hemorrhage have been described. A 55-year-old female patient was admitted to the emergency service due to complaints of dizziness and fainting after headache persisting for several days.
Muhammet Gokhan Turtay, Eren Yigit, Sukru Gurbuz, Mehmet Ediz Sarihan, Hakan Oguzturk, Nur Turkmen   +5 more
doaj   +1 more source

Variants in AKR1D1 and Infant Mortality: Should Bile Acid Screening be a Routine Part of Newborn Screening?

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic pathogenic variants in AKR1D1 cause Δ4‐3‐oxosteroid 5β‐reductase deficiency, disrupt bile acid synthesis, and result in Congenital Bile Acid Synthesis defect type 2 (CBAS2). CBAS2 presents in infancy with cholestasis, coagulopathy, and failure to thrive.
Jade Hudson, Stephanie Hyunh, Bojana Rakic, Cornelius Boerkoel   +3 more
wiley   +1 more source

Deep learning-based multiclass segmentation in aneurysmal subarachnoid hemorrhage

Frontiers in Neurology
IntroductionRadiological scores used to assess the extent of subarachnoid hemorrhage are limited by intrarater and interrater variability and do not utilize all available information from the imaging. Image segmentation enables precise identification and
Julia Kiewitz, Julia Kiewitz, Orhun Utku Aydin, Adam Hilbert, Marie Gultom, Anouar Nouri, Ahmed A. Khalil, Peter Vajkoczy, Satoru Tanioka, Fujimaro Ishida, Nora F. Dengler, Nora F. Dengler, Nora F. Dengler, Dietmar Frey, Dietmar Frey   +14 more
doaj   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

An institutional report of heparin induced thrombocytopenia type II in aneurysmal subarachnoid hemorrhage patients [PDF]

, 2022
Boyi Li, Tolga Sursal, Erick Martinez, Zafar Karimov, Eric Feldstein, Alan Stein, Jared Cooper, Rasheed Hosein‐Woodley, Aiden Liu, Matthew K. McIntyre, Christian A. Bowers, Simon Hanft, Zeeshan Hafeez, Jared M. Pisapia, Carrie R. Muh, Rachana Tyagi, Stephan A. Mayer, Chirag D. Gandhi, Fawaz Al‐Mufti   +18 more
openalex   +1 more source