Results 121 to 130 of about 4,813,728 (301)

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Numerical study of the effects of minor structures and mean velocity fields in the cerebrospinal fluid flow

Fluids and Barriers of the CNS
The importance of optimizing intrathecal drug delivery is highlighted by its potential to improve patient health outcomes. Findings from previous computational studies, based on an individual or a small group, may not be applicable to the wider ...
Ziyu Wang, Mohammad Majidi, Chenji Li, Arezoo Ardekani   +3 more
doaj   +1 more source

Measuring skin to subarachnoid space depth in Egyptian population: A prospective cohort study

, 2016
HaniIbrahim Taman, AhmedMohamed Farid, WaleedMohamed Abdelghaffar   +2 more
openalex   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

Advanced Science, Volume 13, Issue 1, 5 January 2026.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li, Aijun Shen, Xiaolong Gao, Chao Lin, Zongliang Huang, Qi Lv, Junjun Tang, Xiaolong Ma, Jiong Ni, Ju Tian, Jiaqi Wu, Xiaowen Xu, Wei Wang, Peijun Wang   +13 more
wiley   +1 more source

Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus [PDF]

, 2014
Namiko Nishida, Nanae Nagata, Hiroki Toda, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Mitsuhito Mase, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki, Masatsune Ishikawa   +10 more
openalex   +1 more source

Unforeseen Complications: Cauda Equina Syndrome After Vaginoplasty Combined With Epidural Analgesia

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT This case describes the first postoperative complication of cauda equina syndrome following gender affirmation surgery. Postoperatively, an epidural catheter was placed for pain management. Despite its intended benefits, the patient developed symptoms of cauda equina syndrome, a rare but serious neurological condition possibly related to ...
Toni P. Seppälä, Kaisu Ojala
wiley   +1 more source

Early olfactory dysfunction in experimental autoimmune encephalomyelitis reflects transient brain barrier breach and initiation of neuroinflammation in the olfactory bulb

Frontiers in Cellular Neuroscience
Olfactory dysfunction is increasingly recognized as an early, non-motor manifestation of multiple sclerosis (MS), but the mechanisms underlying its occurrence remain unclear.
Andjela Stekic, Milorad Dragic, Milorad Dragic, Ivana Stevanovic, Marina Zaric Kontic, Marija Adzic Bukvic, Sanja Dacic, Milica Ninkovic, Nadezda Nedeljkovic   +8 more
doaj   +1 more source

Schimmelpenning-Feuerstein-Mims syndrome with benign enlargement of subarachnoid space in infancy. [PDF]

BMJ Case Rep, 2023
Maldar SB, Pinto CJ, Kumar U, Vairaprakasam SP.   +3 more
europepmc   +1 more source

Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways

Journal of Cerebral Blood Flow and Metabolism, 2017
B. Bedussi, N. N. van der Wel, J. de Vos, Henk A. van Veen, M. Siebes, E. vanBavel, E. Bakker   +6 more
semanticscholar   +1 more source

Therapeutic Hypothermia Alleviates Hydrocephalus and Neurological Dysfunction Post Intraventricular Hemorrhage by Enhancing Drainage of Glymphatic‐Meningeal Lymphatic‐Deep Cervical Lymphatic System

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
TH is expected to be a novel therapeutic strategy for hydrocephalus and neurological dysfunction post IVH. TH alleviates hydrocephalus post IVH by enhancing drainage of the glymphatic‐meningeal lymphatic‐deep cervical lymphatic system, which is the connection between the central nervous system and peripheral lymphatic system.
Yijian Yang, Qian Ouyang, Yaxin Sun, Aijun Liang, Junqiang Wang, Kaiyue Wang, Yexin Yuan, Zhikun Liu, Jun Huang, Zhiping Zhang, Libin Wang, Yang Yuan, Cheng Wang, Zhangjie Su, Qinghua Zhang, Liyang Zhang, Gelei Xiao   +16 more
wiley   +1 more source