Results 31 to 40 of about 4,813,728 (301)

Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.

Journal of Clinical Investigation, 2019
Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH) defining an unmet need for therapeutic development. Cell-free hemoglobin that is released from erythrocytes into
M. Hugelshofer, R. Buzzi, C. Schaer, H. Richter, Kevin Akeret, Vania Anagnostakou, Leila Mahmoudi, Raphael Vaccani, Florence Vallelian, J. Deuel, P. Kronen, Z. Kulcsár, L. Regli, J. Baek, Ivan S. Pires, A. Palmer, M. Dennler, R. Humar, P. Buehler, P. Kircher, E. Keller, D. Schaer   +21 more
semanticscholar   +1 more source

CSF circulation and dispersion yield rapid clearance from intracranial compartments

Frontiers in Bioengineering and Biotechnology, 2022
In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles.
Martin Hornkjøl, Lars Magnus Valnes, Geir Ringstad, Geir Ringstad, Marie E. Rognes, Marie E. Rognes, Per-Kristian Eide, Per-Kristian Eide, Kent-André Mardal, Kent-André Mardal, Vegard Vinje   +10 more
doaj   +1 more source

The Physiological Occlusion of the Central Canal May Be a Prerequisite for Syringomyelia Formation [PDF]

Neurospine, 2023
Objective Syringomyelia is a common central nervous system disease characterized by the dilation of the central canal (CC). Regarding the pathogenesis of syringomyelia, cerebrospinal fluid (CSF) circulation obstruction in the subarachnoid space (SAS) of ...
Chuan Jiang, Xinyu Wang, Chunli Lu, Qian Li, Longbing Ma, Wei Li, Shengyu Cui, Kang Li, Xiang Wang, Yuxin Feng, Fengzeng Jian   +10 more
doaj   +1 more source

The Human Visual Pathway Communicates Directly With the Subarachnoid Space.

Investigative Ophthalmology and Visual Science, 2019
Purpose Explore in vivo whether there is direct communication between the cerebrospinal fluid (CSF) and extravascular compartment of human visual pathway structures.
H. Jacobsen, G. Ringstad, Ø. K. Jørstad, M. Moe, T. Sandell, P. Eide   +5 more
semanticscholar   +1 more source

Mapping Solute Clearance From the Mouse Hippocampus Using a 3D Imaging Cryomicrotome

Frontiers in Neuroscience, 2021
The hippocampus is susceptible to protein aggregation in neurodegenerative diseases such as Alzheimer’s disease. This protein accumulation is partially attributed to an impaired clearance; however, the removal pathways for fluids and waste products are ...
Daphne M. P. Naessens, Johannes G. G. Dobbe, Judith de Vos, Ed VanBavel, Erik N. T. P. Bakker   +4 more
doaj   +1 more source

Cerebrospinal fluid dynamics along the optic nerve

Frontiers in Neurology, 2022
The cerebrospinal fluid (CSF) plays an important role in delivering nutrients and eliminating the metabolic wastes of the central nervous system. An interrupted CSF flow could cause disorders of the brain and eyes such as Alzheimer's disease and glaucoma.
Jinqiao Sheng, Jinqiao Sheng, Qi Li, Tingting Liu, Xiaofei Wang   +4 more
doaj   +1 more source

A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

PLoS ONE, 2017
Intrathecal drug and gene vector delivery is a procedure to release a solute within the cerebrospinal fluid. This procedure is currently used in clinical practice and shows promise for treatment of several central nervous system pathologies.
P. Haga, G. Pizzichelli, M. Mortensen, M. Kuchta, Soroush H Pahlavian, E. Sinibaldi, B. Martin, K. Mardal   +7 more
semanticscholar   +1 more source

Perfluorocarbon liquid migration into the subarachnoid space in a patient with morning glory syndrome

Journal of Current Ophthalmology, 2015
Purpose: To report a case of perfluorocarbon liquid (PFCL) migration into the subarachnoid space at the time of vitreoretinal surgery in a patient with morning glory syndrome associated retinal detachment.
Masood Naseripour, Adel Ghasempour, Khalil Ghasemi Falavarjani, Mostafa Sultan Sanjari, Maryam Yousefi   +4 more
doaj   +1 more source

Absence of Disproportionately Enlarged Subarachnoid Space Hydrocephalus, a Sharp Callosal Angle, or Other Morphologic MRI Markers Should Not Be Used to Exclude Patients with Idiopathic Normal Pressure Hydrocephalus from Shunt Surgery

American Journal of Neuroradiology, 2018
BACKGROUND AND PURPOSE: Several studies have evaluated the use of MR imaging markers for the prediction of outcome after shunt surgery in idiopathic normal pressure hydrocephalus with conflicting results.
S. Agerskov, M. Wallin, P. Hellström, D. Ziegelitz, C. Wikkelsö, M. Tullberg   +5 more
semanticscholar   +1 more source

The effect of increased intra-abdominal pressure on orbital subarachnoid space width and intraocular pressure

Neural Regeneration Research, 2018
In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can relieve glaucomatous optic neuropathy.
Su-meng Liu, Ning-li Wang, Zhen-tao Zuo, Wei-wei Chen, Di-ya Yang, Zhen Li, Yi-wen Cao   +6 more
doaj   +1 more source